LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Chinese (Han)
- Study Design
- Three SNPs in FOXO1A and three in FOXO3A were analyzed in a sample of 760 centenarians (578 female and 182 male) and 1060 middle-age controls (378 female and 682 male)
- Conclusions
- In FOXO1A, rs2755209 and rs2755213 were found to be negatively associated with longevity in women (OR = 0.70 and 0.71, p = .007 and .015; dominant model). In the dominant model for men, FOXO1A-rs2755213 was marginally and negatively associated with longevity (OR = 0.65, p = .025) and the association of FOXO1A- rs2755209 is not significant (OR = 0.73, p = .093).
Gene details
- HGNC symbol
- FOXO1
- Aliases
- FKH1; FKHR; FOXO1A
- Common name
- forkhead box O1
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 30
- OMIM
- 136533
- Ensembl
- ENSG00000150907
- UniProt/Swiss-Prot
- FOXO1_HUMAN
- Entrez Gene
- 2308
- UniGene
- 370666
- HapMap
- View on HapMap