LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Ashkenazi Jewish
- Study Design
- 205 centenarians (141 females, median age = 97 years and 64 males, median age = 97 years), their offspring (n = 145 total, 80 females, median age = 69 years and 65 males median age = 68 years), and 288 controls (167 females, median age = 74 years and 121 males, median age = 75 years) were examined for the association between genotype and longevity
- Conclusions
- A U-shape pattern of MTP CC genotype frequency with aging was observed. The CC was a buffered-deleterious genotype in the case group. In the control group without longevity genes, CC genotype included poorer survivorship.
- Identifier
- rs5882
- In Other Studies (IDs)
- 667 1300
- Cytogenetic Location
- 16q13
- UCSC Genome Browser
- View 16q13 on the UCSC genome browser
Gene details
- HGNC symbol
- CETP
- Aliases
- BPIFF; HDLCQ10
- Common name
- cholesteryl ester transfer protein
- Description
- The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]
- Other longevity studies of this gene
- 17
- OMIM
- 118470
- Ensembl
- ENSG00000087237
- UniProt/Swiss-Prot
- A0A0S2Z3F6_HUMAN
- Entrez Gene
- 1071
- UniGene
- 89538
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- cetp
In other databases
- GenAge human genes
- This gene is present as CETP