LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Ashkenazi Jewish
- Study Design
- A group of centenarians (213), their offspring (216), and an age-matched control group (258) were genotyped for 66 polymorphisms in 36 candidate genes related to cardiovascular disease
- Conclusions
- The prevalence of homozygosity for the 641C allele in the APOC3 promoter (rs2542052) was higher in centenarians (25%) and their offspring (20%) than in controls (10%). This genotype was associated with significantly lower serum levels of APOC3, a favorable pattern of lipoprotein levels and sizes. A lower prevalence of hypertension and greater insulin sensitivity in the 641C homozygotes was also found.
- Identifier
- rs2542052
- In Other Studies (IDs)
- 1949
- Cytogenetic Location
- 11q23.3
- UCSC Genome Browser
- View 11q23.3 on the UCSC genome browser
Gene details
- HGNC symbol
- APOC3
- Aliases
- HALP2; APOCIII
- Common name
- apolipoprotein C3
- Description
- Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 7
- OMIM
- 107720
- Ensembl
- ENSG00000110245
- UniProt/Swiss-Prot
- A3KPE2_HUMAN
- Entrez Gene
- 345
- UniGene
- 73849
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge human genes
- This gene is present as APOC3