LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Identifier
- rs35767
- In Other Studies (IDs)
- 465
- Cytogenetic Location
- 12q23.2
- UCSC Genome Browser
- View 12q23.2 on the UCSC genome browser
Gene details
- HGNC symbol
- IGF1
- Aliases
- MGF; IGFI; IGF-I
- Common name
- insulin like growth factor 1
- Description
- The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
- Other longevity studies of this gene
- 9
- OMIM
- 147440
- Ensembl
- ENSG00000017427
- UniProt/Swiss-Prot
- IGF1_HUMAN
- Entrez Gene
- 3479
- UniGene
- 160562
- HapMap
- View on HapMap