LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Identifier
- rs2569190
- In Other Studies (IDs)
- 2140
- Cytogenetic Location
- 5q31.3
- UCSC Genome Browser
- View 5q31.3 on the UCSC genome browser
Gene details
- HGNC symbol
- CD14
- Aliases
- Common name
- CD14 molecule
- Description
- The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]
- Other longevity studies of this gene
- 5
- OMIM
- 158120
- Ensembl
- ENSG00000170458
- UniProt/Swiss-Prot
- CD14_HUMAN
- Entrez Gene
- 929
- UniGene
- 163867
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
- GenAge microarray genes
- This gene is present as CD14