LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Identifier
- rs4998557
- In Other Studies (IDs)
- 2134 3052
- Cytogenetic Location
- 21q22.11
- UCSC Genome Browser
- View 21q22.11 on the UCSC genome browser
Gene details
- HGNC symbol
- SOD1
- Aliases
- ALS; SOD; ALS1; IPOA; hSod1; HEL-S-44; homodimer
- Common name
- superoxide dismutase 1
- Description
- The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 7
- OMIM
- 147450
- Ensembl
- ENSG00000142168
- UniProt/Swiss-Prot
- SODC_HUMAN
- Entrez Gene
- 6647
- UniGene
- 443914
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- sod-5
- Danio rerio
- sod1
- Drosophila melanogaster
- Sod
- Mus musculus
- Sod1
- Rattus norvegicus
- Sod1
- Saccharomyces cerevisiae
- SOD1
- Schizosaccharomyces pombe
- sod1