LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Identifier
- rs2374983
- In Other Studies (IDs)
- 1398 1449
- Cytogenetic Location
- 7q21.3
- UCSC Genome Browser
- View 7q21.3 on the UCSC genome browser
Gene details
- HGNC symbol
- PPP1R9A
- Aliases
- NRB1; NRBI; Neurabin-I
- Common name
- protein phosphatase 1 regulatory subunit 9A
- Description
- This gene is imprinted, and located in a cluster of imprinted genes on chromosome 7q12. This gene is transcribed in both neuronal and multiple embryonic tissues, and it is maternally expressed mainly in embryonic skeletal muscle tissues and biallelically expressed in other embryonic tissues. The protein encoded by this gene includes a PDZ domain and a sterile alpha motif (SAM). It is a regulatory subunit of protein phosphatase I, and controls actin cytoskeleton reorganization. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
- Other longevity studies of this gene
- 5
- OMIM
- 602468
- Ensembl
- ENSG00000158528
- UniProt/Swiss-Prot
- A4D1I0_HUMAN
- Entrez Gene
- 55607
- UniGene
- 21816
- HapMap
- View on HapMap