LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Chinese
- Study Design
- The contribution to ankle-brachial index, development of cardiovascular disease and mortality of ACE I/D was examined in 4000 individuals( >65 y) during a four years follow-up study
- Conclusions
- Although D/D genotype was associated with mortality only in men, the D/D genotype had the greatest reduction in mean ankle-brachial index after adjusting for confounding factors and it also more common among women who developed hypertension or myocardial infarction. There are gender differences in the relationship between D/D genotype and cardiovascular diseases.
Gene details
- HGNC symbol
- ACE
- Aliases
- DCP; ACE1; DCP1; CD143
- Common name
- angiotensin I converting enzyme
- Description
- This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
- Other longevity studies of this gene
- 32
- OMIM
- 106180
- Ensembl
- ENSG00000159640
- UniProt/Swiss-Prot
- ACE_HUMAN
- Entrez Gene
- 1636
- UniGene
- 298469
- HapMap
- View on HapMap