LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 38 genes (311 SNPs) belonging to pro-antioxidant pathways were investigated for the association with physical and cognitive performances in a Cohort of 1089 Danish nonagenarians. For each gene analyzed in the pro-antioxidant pathway, the influence on longitudinal survival was tested.
- Conclusions
- No gene found associated with a functional phenotype showed a corresponding association with survival in the whole cohort. NDUFS1, TXNRD1, SOD2 and UCP3 were found significantly associated with lifespan in the female cohort. No association with survival was reported in males for genes belonging to the pro-oxidant pathway here analyzed.
- Identifier
- rs2375005
- In Other Studies (IDs)
- 2101
- Cytogenetic Location
- 7q21.3
- UCSC Genome Browser
- View 7q21.3 on the UCSC genome browser
Gene details
- HGNC symbol
- PON2
- Aliases
- Common name
- paraoxonase 2
- Description
- This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 14
- OMIM
- 602447
- Ensembl
- ENSG00000105854
- UniProt/Swiss-Prot
- A0A0J9YYG4_HUMAN
- Entrez Gene
- 5445
- UniGene
- 514420
- HapMap
- View on HapMap