LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Danish
- Study Design
- 592 SNPs from 77 genes involved in nine sub-processes were analyzed in 1089 long-lived and 736 middle-aged Danes. Then, a replicated study was carried out in a German cohort.
- Conclusions
- The results did not remain significant after correction. The findings drawn from the Danish cohort were not replicated in German samples.
- Identifier
- rs3219142
- In Other Studies (IDs)
- 854
- Cytogenetic Location
- 1q42.12
- UCSC Genome Browser
- View 1q42.12 on the UCSC genome browser
Gene details
- HGNC symbol
- PARP1
- Aliases
- PARP; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT; 1; pADPRT-1
- Common name
- poly(ADP-ribose) polymerase 1
- Description
- This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 15
- OMIM
- 173870
- Ensembl
- ENSG00000143799
- UniProt/Swiss-Prot
- A0A024R3T8_HUMAN
- Entrez Gene
- 142
- UniGene
- 177766
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- pme-1
- Danio rerio
- parp1
- Drosophila melanogaster
- Parp
- Mus musculus
- Parp1
- Rattus norvegicus
- Parp1