LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Italian
- Study Design
- Two polymorphisms were studied for effects on survival in 668 individuals aged 70-105.5 years and followed for 7 years
- Conclusions
- Male carriers of A/A genotype in rs2229765 lived longed
- Identifier
- rs2229765
- In Other Studies (IDs)
- 1679 2199
- Cytogenetic Location
- 15q26.3
- UCSC Genome Browser
- View 15q26.3 on the UCSC genome browser
Gene details
- HGNC symbol
- IGF1R
- Aliases
- IGFR; CD221; IGFIR; JTK13
- Common name
- insulin like growth factor 1 receptor
- Description
- This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
- Other longevity studies of this gene
- 10
- OMIM
- 147370
- Ensembl
- ENSG00000140443
- UniProt/Swiss-Prot
- C9J5X1_HUMAN
- Entrez Gene
- 3480
- UniGene
- 643120
- HapMap
- View on HapMap