LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A sample of 277 unrelated individuals (>70 years old, mean age, 82.9) was recruited in 2000 and genotyped. On the basis of mortality data collected in 2009, the sample was divided into two groups of subjects surviving over 90 years (long-lived) or not (controls).
- Conclusions
- The frequency of the FSHR 680 Ser/Ser genotype was significantly higher in the sample of long-lived women compared to controls, indicating that the FSHR 680 Ser/Ser genotype may favor survival to more than 90 years of age in women only
- Identifier
- rs6166
- Cytogenetic Location
- 2p16.3
- UCSC Genome Browser
- View 2p16.3 on the UCSC genome browser
Gene details
- HGNC symbol
- FSHR
- Aliases
- LGR1; ODG1; FSHR1; FSHRO
- Common name
- follicle stimulating hormone receptor
- Description
- The protein encoded by this gene belongs to family 1 of G-protein coupled receptors. It is the receptor for follicle stimulating hormone and functions in gonad development. Mutations in this gene cause ovarian dysgenesis type 1, and also ovarian hyperstimulation syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
- OMIM
- 136435
- Ensembl
- ENSG00000170820
- UniProt/Swiss-Prot
- A0A1D5RMN4_HUMAN
- Entrez Gene
- 2492
- UniGene
- 1428
- HapMap
- View on HapMap