LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- American (Caucasian)
- Study Design
- Common polymorphisms in the ADRB2 gene were studied for association with survival and longevity in the Framingham Heart Study Offspring cohort for which data was available for 1565 subjects
- Conclusions
- The Gln27Glu and Glu27Glu genotypes and the Glu27 allele were associated with shorter lifespans at young-old ages (cut-off = 72 years) and longer lives in oldest-old ages (e.g., cut-off = 83 years) compared to carriers of the Gln27Gln genotype. The Gln(27)Gln genotype was also associated with age-related diseases, such as cancer.
- Identifier
- rs1042714
- In Other Studies (IDs)
- 1270
- Cytogenetic Location
- 5q32
- UCSC Genome Browser
- View 5q32 on the UCSC genome browser
Gene details
- HGNC symbol
- ADRB2
- Aliases
- BAR; B2AR; ADRBR; ADRB2R; BETA2AR
- Common name
- adrenoceptor beta 2
- Description
- This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 6
- OMIM
- 109690
- Ensembl
- ENSG00000169252
- UniProt/Swiss-Prot
- ADRB2_HUMAN
- Entrez Gene
- 154
- UniGene
- 2551
- HapMap
- View on HapMap