LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Chinese (Han)
- Study Design
- Six tagging SNPs from FOXO1A and FOXO3A were selected and genotyped in 1817 centenarians and younger individuals
- Conclusions
- All 3 SNPs of FOXO3A were associated with longevity in both genders (P = 0.005-0.001)
- Identifier
- rs2253310
- In Other Studies (IDs)
- 1674 2242
- Cytogenetic Location
- 6q21
- UCSC Genome Browser
- View 6q21 on the UCSC genome browser
Gene details
- HGNC symbol
- FOXO3
- Aliases
- FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
- Common name
- forkhead box O3
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 101
- OMIM
- 602681
- Ensembl
- ENSG00000118689
- UniProt/Swiss-Prot
- FOXO3_HUMAN
- Entrez Gene
- 2309
- UniGene
- 220950
- HapMap
- View on HapMap