LongevityMap variant

Entry Details

Longevity Association: Non-significant
Population: Italian
Study Design: Exon 9 AvaII RFLP polymorphism was examined in 219 centenarians (72 males and 147 females) and 256 (controls 20-70 years, 119 males and 137 females)
Conclusions: No significant difference between centenarians and controls was observed

HGNC symbol: IGF2
Aliases: GRDF; IGF-II; PP9974; C11orf43
Common name: insulin like growth factor 2
Description: This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Other longevity studies of this gene: 6
OMIM: 147470
Ensembl: ENSG00000167244
UniProt/Swiss-Prot: E3UN46_HUMAN
Entrez Gene: 3481
UniGene: 272259
HapMap: View on HapMap

GenAge human genes

De Luca et al. (2001)