LongevityMap variant

Entry Details

Longevity Association: Significant
Population: Dutch
Study Design: Studied genetic variation in the insulin/insulin-like growth factor signaling (IIS) pathway and in the telomere maintenance pathway for associations with longevity in 403 unrelated nonagenarians and 1,670 younger controls
Conclusions: SNP sets in both pathways were associated with longevity with the association of the IIS pathway defined by several genes (AKT1, AKT3, FOXO4, IGF2, INS, PIK3CA, SGK, SGK2, and YWHAG), while the telomere maintenance pathway seemed to be mainly determined by POT1 since only these genes showed an association with longevity

HGNC symbol: AKT1
Aliases: AKT; PKB; RAC; CWS6; PRKBA; PKB-ALPHA; RAC-ALPHA
Common name: AKT serine/threonine kinase 1
Description: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
Other longevity studies of this gene: 9
OMIM: 164730
Ensembl: ENSG00000142208
UniProt/Swiss-Prot: AKT1_HUMAN
Entrez Gene: 207
UniGene: 525622
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

CellAge

Deelen et al. (2013)