LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- German
- Study Design
- Targeted investigation of 500 SNPs in 343 selected genes associated with longevity in model systems. A sample of 386 unrelated German centenarians (mean age: 101.3 years) and 410 control subjects (mean age: 66.6 years) were studied.
- Conclusions
- No significant associations were found after correcting for multiple testing, though three SNPs (rs770087, rs2301582 and rs648802 in, respectively, DUSP6, NALP1 and PERP) had a suggestive association. This association was not confirmed in an independent French collection of 541 centenarians and 469 younger controls.
Variants (3)
DUSP6
Gene details
- HGNC symbol
- DUSP6
- Aliases
- HH19; MKP3; PYST1
- Common name
- dual specificity phosphatase 6
- Description
- The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK2, is expressed in a variety of tissues with the highest levels in heart and pancreas, and unlike most other members of this family, is localized in the cytoplasm. Mutations in this gene have been associated with congenital hypogonadotropic hypogonadism. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2014]
- OMIM
- 602748
- Ensembl
- ENSG00000139318
- UniProt/Swiss-Prot
- A0A024RBC1_HUMAN
- Entrez Gene
- 1848
- UniGene
- 298654
- HapMap
- View on HapMap
Homologs in model organisms
In other databases
NLRP1
Gene details
- HGNC symbol
- NLRP1
- Aliases
- NAC; MSPC; AIADK; CARD7; CIDED; NALP1; SLEV1; DEFCAP; PP1044; VAMAS1; CLR17.1; DEFCAP-L/S
- Common name
- NLR family pyrin domain containing 1
- Description
- This gene encodes a member of the Ced-4 family of apoptosis proteins. Ced-family members contain a caspase recruitment domain (CARD) and are known to be key mediators of programmed cell death. The encoded protein contains a distinct N-terminal pyrin-like motif, which is possibly involved in protein-protein interactions. This protein interacts strongly with caspase 2 and weakly with caspase 9. Overexpression of this gene was demonstrated to induce apoptosis in cells. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
- OMIM
- 606636
- Ensembl
- ENSG00000091592
- UniProt/Swiss-Prot
- NLRP1_HUMAN
- Entrez Gene
- 22861
- UniGene
- 652273
- HapMap
- View on HapMap
Homologs in model organisms
PERP
Gene details
- HGNC symbol
- PERP
- Aliases
- THW; KCP1; PIGPC1; KRTCAP1; dJ496H19.1
- Common name
- PERP, TP53 apoptosis effector
- Description
- OMIM
- 609301
- Ensembl
- ENSG00000112378
- UniProt/Swiss-Prot
- PERP_HUMAN
- Entrez Gene
- 64065
- UniGene
- 201446
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- vab-9
- Danio rerio
- perp
- Drosophila melanogaster
- CG6982
- Mus musculus
- Perp
- Rattus norvegicus
- Perp
In other databases
- CellAge gene expression
- This gene is present as PERP