LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- American (Caucasian)
- Study Design
- Genome-wide association study for longevity-related traits in up to 1345 Framingham Study participants from 330 families; 713 participants achieved age 65 years or greater. A total of 79 potential candidate genes and regions associated with longevity were also studied.
- Conclusions
- Although no genome-wide associations were significant, mutiple SNPs and genes had suggestive associations with age at death
Variants (9)
- Gene summary:
- No gene (5)
- LOC105374956 (1)
- MYLIP (1)
- NXPH2 (1)
- OR4Q3 (1)
No gene
LOC105374956
Gene details
- HGNC symbol
- LOC105374956
- Aliases
- Common name
- uncharacterized LOC105374956
- Description
- OMIM
- Ensembl
- UniProt/Swiss-Prot
- Entrez Gene
- 105374956
- UniGene
- 561599
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
MYLIP
Gene details
- HGNC symbol
- MYLIP
- Aliases
- MIR; IDOL
- Common name
- myosin regulatory light chain interacting protein
- Description
- The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth. [provided by RefSeq, Jul 2008]
- OMIM
- 610082
- Ensembl
- ENSG00000007944
- UniProt/Swiss-Prot
- MYLIP_HUMAN
- Entrez Gene
- 29116
- UniGene
- 484738
- HapMap
- View on HapMap
Homologs in model organisms
NXPH2
Gene details
- HGNC symbol
- NXPH2
- Aliases
- NPH2
- Common name
- neurexophilin 2
- Description
- OMIM
- 604635
- Ensembl
- ENSG00000144227
- UniProt/Swiss-Prot
- NXPH2_HUMAN
- Entrez Gene
- 11249
- UniGene
- 435019
- HapMap
- View on HapMap
Homologs in model organisms
OR4Q3
Gene details
- HGNC symbol
- OR4Q3
- Aliases
- HSA6; OR4Q4; OR14-3; C14orf13; c14_5008
- Common name
- olfactory receptor family 4 subfamily Q member 3
- Description
- Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
- OMIM
- Ensembl
- ENSG00000182652
- UniProt/Swiss-Prot
- A0A126GW32_HUMAN
- Entrez Gene
- 441669
- UniGene
- 553828
- HapMap
- View on HapMap
Homologs in model organisms
- Mus musculus
- Olfr735