LongevityMap variant group

Entry Details

Longevity Association: Non-significant
Population: Italian (Northern) and Japanese
Study Design: AGTR1 was sequenced in 173 Italian centenarians (99-106 y, mean 100.9 ± 1.7 y, 83% female) and 376 younger controls (49-78 y, mean 65.9 ± 9.1 y, 43 % females). The results were then verified in 589 Japanese cases (99-115 y, mean 104.5 ± 3 y, 84% femal) and 422 controls (69-72 y, mean 70.1 ± 0.9 y, 52 % female).
Conclusions: rs422858, rs275653 were significantly associated with extreme longevity (P = 0.004). Other SNPs were not associated with longevity.

HGNC symbol: AGTR1
Aliases: AT1; AG2S; AT1B; AT1R; AT1AR; AT1BR; AT2R1; HAT1R; AGTR1B
Common name: angiotensin II receptor type 1
Description: Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. Multiple alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Jul 2012]
Other longevity studies of this gene: 8
OMIM: 106165
Ensembl: ENSG00000144891
UniProt/Swiss-Prot: A0A0A0MSE3_HUMAN
Entrez Gene: 185
UniGene: 477887
HapMap: View on HapMap

GenAge model organism genes

GenAge human genes

HGNC symbol: WDR13
Aliases: MG21
Common name: WD repeat domain 13
Description: This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by Gly-His and Trp-Asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. A similar protein in mouse is thought to be a negative regulator of the pancreatic beta cell proliferation. Mice lacking this gene exhibit increased pancreatic islet mass and higher serum insulin levels, and are mildly obese. [provided by RefSeq, Nov 2016]
OMIM: 300512
Ensembl: ENSG00000101940
UniProt/Swiss-Prot: WDR13_HUMAN
Entrez Gene: 64743
UniGene: 521973
HapMap: View on HapMap