LongevityMap variant group
Entry Details
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- Using a tagging approach, the possible associations between longevity and the common genetic variation at the three bitter taste receptor gene clusters on chromosomes 5, 7 and 12 in a population of 941 unrelated individuals (20-106 years old) was investigated. The study included 348 very elderly cases (>=85 years, mean age 93.82 years, median age 92) and 593 non-elderly controls (<85 years, mean age 59.17 years, median age 67 years).
- Conclusions
- None of the tested single nucleotide polymorphisms, excepting rs978739, showed a significant association with the longevity phenotype
Variants (38)
- Gene summary:
- No gene (3)
- PRH1 (12)
- TAS2R1 (1)
- TAS2R16 (3)
- TAS2R20 (3)
- TAS2R3 (1)
- TAS2R30 (1)
- TAS2R38 (3)
- TAS2R39 (1)
- TAS2R4 (2)
- TAS2R40 (1)
- TAS2R41 (2)
- TAS2R42 (1)
- TAS2R5 (1)
- TAS2R60 (1)
- TAS2R7 (1)
- TAS2R9 (1)
No gene
PRH1
Gene details
- HGNC symbol
- PRH1
- Aliases
- PA; Db-s; PRH2; PIF-S; Pr1/Pr2
- Common name
- proline rich protein HaeIII subfamily 1
- Description
- This gene encodes a member of the heterogeneous family of proline-rich salivary glycoproteins. The encoded preproprotein undergoes proteolytic processing to generate one or more mature isoforms before secretion from the parotid and submandibular/sublingual glands. Multiple distinct alleles of this locus including the parotid isoelectric-focusing variant slow (PIF-s), the parotid acidic protein (Pa), and the double band slow (Db-s) isoforms have been characterized. The reference genome encodes the Db-s allele. Certain alleles of this gene are associated with susceptibility to dental caries. This gene is located in a cluster of closely related salivary proline-rich proteins on chromosome 12. Co-transcription of this gene with adjacent genes has been observed. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]
- Other longevity studies of this gene
- 11
- OMIM
- 168730
- Ensembl
- ENSG00000231887
- UniProt/Swiss-Prot
- A0A087WV42_HUMAN
- Entrez Gene
- 5554
- UniGene
- 656965
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
TAS2R1
Gene details
- HGNC symbol
- TAS2R1
- Aliases
- T2R1; TRB7
- Common name
- taste 2 receptor member 1
- Description
- This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. This intronless taste receptor gene encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is mapped to chromosome 5p15, the location of a genetic locus (PROP) that controls the detection of the bitter compound 6-n-propyl-2-thiouracil. [provided by RefSeq, Jul 2008]
- OMIM
- 604796
- Ensembl
- ENSG00000169777
- UniProt/Swiss-Prot
- Q502V6_HUMAN
- Entrez Gene
- 50834
- UniGene
- 567492
- HapMap
- View on HapMap
Homologs in model organisms
TAS2R16
Gene details
- HGNC symbol
- TAS2R16
- Aliases
- T2R16
- Common name
- taste 2 receptor member 16
- Description
- This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily. These family members are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 3
- OMIM
- 604867
- Ensembl
- ENSG00000128519
- UniProt/Swiss-Prot
- T2R16_HUMAN
- Entrez Gene
- 50833
- UniGene
- 272395
- HapMap
- View on HapMap
Homologs in model organisms
- Danio rerio
- tas2r200.1
- Mus musculus
- Tas2r16
- Rattus norvegicus
- Tas2r16
TAS2R20
Gene details
- HGNC symbol
- TAS2R20
- Aliases
- T2R20; T2R49; T2R56; TAS2R49
- Common name
- taste 2 receptor member 20
- Description
- This gene encodes a member of the taste receptor two family of class C G-protein coupled receptors. Receptors of this family have a short extracellular N-terminus, seven transmembrane helices, three extracellular loops and three intracellular loops, and an intracellular C-terminus. Members of this family are expressed in a subset of taste receptor cells, where they function in bitter taste reception, as well as in non-gustatory cells including those of the brain, reproductive organs, respiratory system, and gastrointestinal system. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2016]
- Other longevity studies of this gene
- 2
- OMIM
- 613962
- Ensembl
- ENSG00000255837
- UniProt/Swiss-Prot
- T2R20_HUMAN
- Entrez Gene
- 259295
- UniGene
- 686384
- HapMap
- View on HapMap
Homologs in model organisms
- Rattus norvegicus
- Tas2r120
TAS2R3
Gene details
- HGNC symbol
- TAS2R3
- Aliases
- T2R3
- Common name
- taste 2 receptor member 3
- Description
- This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless taste receptor genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
- OMIM
- 604868
- Ensembl
- ENSG00000127362
- UniProt/Swiss-Prot
- TA2R3_HUMAN
- Entrez Gene
- 50831
- UniGene
- 676011
- HapMap
- View on HapMap
Homologs in model organisms
TAS2R30
Gene details
- HGNC symbol
- TAS2R30
- Aliases
- T2R30; T2R47; TAS2R47
- Common name
- taste 2 receptor member 30
- Description
- OMIM
- 613963
- Ensembl
- ENSG00000256188
- UniProt/Swiss-Prot
- T2R30_HUMAN
- Entrez Gene
- 259293
- UniGene
- 679464
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
TAS2R38
Gene details
- HGNC symbol
- TAS2R38
- Aliases
- PTC; T2R38; T2R61
- Common name
- taste 2 receptor member 38
- Description
- This gene encodes a seven-transmembrane G protein-coupled receptor that controls the ability to taste glucosinolates, a family of bitter-tasting compounds found in plants of the Brassica sp. Synthetic compounds phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP) have been identified as ligands for this receptor and have been used to test the genetic diversity of this gene. Although several allelic forms of this gene have been identified worldwide, there are two predominant common forms (taster and non-taster) found outside of Africa. These alleles differ at three nucleotide positions resulting in amino acid changes in the protein (A49P, A262V, and V296I) with the amino acid combination PAV identifying the taster variant (and AVI identifying the non-taster variant). [provided by RefSeq, Oct 2009]
- Other longevity studies of this gene
- 2
- OMIM
- 607751
- Ensembl
- ENSG00000257138
- UniProt/Swiss-Prot
- T2R38_HUMAN
- Entrez Gene
- 5726
- UniGene
- 647085
- HapMap
- View on HapMap
Homologs in model organisms
TAS2R39
Gene details
- HGNC symbol
- TAS2R39
- Aliases
- T2R39; T2R57
- Common name
- taste 2 receptor member 39
- Description
- The protein encoded by this gene is a bitter taste receptor that detects green tea catechins, soy isoflavones, and theaflavins. The encoded protein is gustducin-linked and may activate alpha gustducin. This gene is intronless. [provided by RefSeq, Dec 2015]
- OMIM
- Ensembl
- ENSG00000236398
- UniProt/Swiss-Prot
- T2R39_HUMAN
- Entrez Gene
- 259285
- UniGene
- 553660
- HapMap
- View on HapMap
Homologs in model organisms
TAS2R4
Gene details
- HGNC symbol
- TAS2R4
- Aliases
- T2R4
- Common name
- taste 2 receptor member 4
- Description
- This gene encodes a member of a family of candidate taste receptors that are members of the G protein-coupled receptor superfamily and that are specifically expressed by taste receptor cells of the tongue and palate epithelia. These apparently intronless genes encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes in chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 1
- OMIM
- 604869
- Ensembl
- ENSG00000127364
- UniProt/Swiss-Prot
- TA2R4_HUMAN
- Entrez Gene
- 50832
- UniGene
- 735690
- HapMap
- View on HapMap
Homologs in model organisms
TAS2R40
Gene details
- HGNC symbol
- TAS2R40
- Aliases
- GPR60; T2R40; T2R58
- Common name
- taste 2 receptor member 40
- Description
- OMIM
- 613964
- Ensembl
- ENSG00000221937
- UniProt/Swiss-Prot
- T2R40_HUMAN
- Entrez Gene
- 259286
- UniGene
- 352241
- HapMap
- View on HapMap
Homologs in model organisms
TAS2R41
Gene details
- HGNC symbol
- TAS2R41
- Aliases
- T2R41; T2R59
- Common name
- taste 2 receptor member 41
- Description
- Other longevity studies of this gene
- 1
- OMIM
- 613965
- Ensembl
- ENSG00000221855
- UniProt/Swiss-Prot
- T2R41_HUMAN
- Entrez Gene
- 259287
- UniGene
- 650648
- HapMap
- View on HapMap
Homologs in model organisms
TAS2R42
Gene details
- HGNC symbol
- TAS2R42
- Aliases
- T2R24; T2R42; T2R55; TAS2R55
- Common name
- taste 2 receptor member 42
- Description
- OMIM
- 613966
- Ensembl
- ENSG00000186136
- UniProt/Swiss-Prot
- A0A0G2JPZ2_HUMAN
- Entrez Gene
- 353164
- UniGene
- 553716
- HapMap
- View on HapMap
Homologs in model organisms
TAS2R5
Gene details
- HGNC symbol
- TAS2R5
- Aliases
- T2R5
- Common name
- taste 2 receptor member 5
- Description
- This gene encodes a bitter taste receptor; bitter taste receptors are members of the G protein-coupled receptor superfamily and are specifically expressed by taste receptor cells of the tongue and palate epithelia. Each of these apparently intronless taste receptor genes encodes a 7-transmembrane receptor protein, functioning as a bitter taste receptor. This gene is clustered with another 3 candidate taste receptor genes on chromosome 7 and is genetically linked to loci that influence bitter perception. [provided by RefSeq, Jul 2008]
- OMIM
- 605062
- Ensembl
- ENSG00000127366
- UniProt/Swiss-Prot
- A4D1U0_HUMAN
- Entrez Gene
- 54429
- UniGene
- 675370
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found
TAS2R60
Gene details
- HGNC symbol
- TAS2R60
- Aliases
- T2R56; T2R60
- Common name
- taste 2 receptor member 60
- Description
- OMIM
- 613968
- Ensembl
- ENSG00000185899
- UniProt/Swiss-Prot
- T2R60_HUMAN
- Entrez Gene
- 338398
- UniGene
- 688222
- HapMap
- View on HapMap
Homologs in model organisms
TAS2R7
Gene details
- HGNC symbol
- TAS2R7
- Aliases
- T2R7; TRB4
- Common name
- taste 2 receptor member 7
- Description
- This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
- OMIM
- 604793
- Ensembl
- ENSG00000121377
- UniProt/Swiss-Prot
- TA2R7_HUMAN
- Entrez Gene
- 50837
- UniGene
- 533754
- HapMap
- View on HapMap
Homologs in model organisms
TAS2R9
Gene details
- HGNC symbol
- TAS2R9
- Aliases
- T2R9; TRB6
- Common name
- taste 2 receptor member 9
- Description
- This gene product belongs to the family of candidate taste receptors that are members of the G-protein-coupled receptor superfamily. These proteins are specifically expressed in the taste receptor cells of the tongue and palate epithelia. They are organized in the genome in clusters and are genetically linked to loci that influence bitter perception in mice and humans. In functional expression studies, they respond to bitter tastants. This gene maps to the taste receptor gene cluster on chromosome 12p13. [provided by RefSeq, Jul 2008]
- OMIM
- 604795
- Ensembl
- ENSG00000121381
- UniProt/Swiss-Prot
- TA2R9_HUMAN
- Entrez Gene
- 50835
- UniGene
- 272391
- HapMap
- View on HapMap
Homologs in model organisms
No homologs found