AnAge entry for Danio rerio
Classification (HAGRID: 03544)
- Taxonomy
-
Kingdom: Animalia
Phylum: Chordata
Class: Teleostei
Order: Cypriniformes
Family: Cyprinidae
Genus: Danio
- Species
- Danio rerio
- Common name
- Zebra danio or zebrafish
- Synonyms
- Brachydanio rerio, Cyprinus rerio
Lifespan, ageing, and relevant traits
- Maximum longevity
- 5.5 years (captivity)
- Source
- ref. 3
- Sample size
- Large
- Data quality
- High
- Observations
Outbred zebrafish have a mean lifespan of 3.5 years and can live up to 5.5 years. They exhibit a gradual ageing process. A spinal curvature was reported to be a common age-related phenotype [0003]. Zebrafish show a decline in exercise capacity that parallels that of mammalian ageing. Whole organism performance and trainability decrease with age [1167]. The zebrafish heart appears to have a robust capacity for regeneration based on the proliferation of cardiomyocytes which can avoid scar formation and allow cardiac regeneration [0482]. One study reported that gene expression changes in ageing zebrafish brains are sexually dimorphic. The most notable differentially expressed genes were those related to neurogenesis, cell differentiation, and brain and nervous system development [1168].
Life history traits (averages)
- No information is available on life history. Please contact us if you wish to suggest or contribute data.
Metabolism
No information on metabolism is available.
Species in other databases
References
- [1251] Carneiro et al. (2016), Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish (PubMed)
- [1168] Arslan-Ergul and Adams (2014), Gene expression changes in aging zebrafish (Danio rerio) brains are sexually dimorphic (PubMed)
- [1167] Gilbert et al. (2014), Zebrafish (Danio rerio) as a model for the study of aging and exercise: physical ability and trainability decrease with age (PubMed)
- [1105] Itou et al. (2012), Life-long preservation of the regenerative capacity in the fin and heart in zebrafish (PubMed)
- [0802] Tsai et al. (2007), Differential effects of genotoxic stress on both concurrent body growth and gradual senescence in the adult zebrafish (PubMed)
- [0607] Dou et al. (2006), Co-evolutionary analysis of insulin/insulin like growth factor 1 signal pathway in vertebrate species (PubMed)
- [0140] Kishi (2004), Functional aging and gradual senescence in zebrafish (PubMed)
- [0662] Herrera and Jagadeeswaran (2004), Annual fish as a genetic model for aging (PubMed)
- [0070] Gerhard (2003), Comparative aspects of zebrafish (Danio rerio) as a model for aging research (PubMed)
- [0141] Murtha and Keller (2003), Characterization of the heat shock response in mature zebrafish (Danio rerio) (PubMed)
- [0071] Gerhard and Cheng (2002), A call to fins! Zebrafish as a gerontological model (PubMed)
- [0482] Poss et al. (2002), Heart regeneration in zebrafish (PubMed)
- [0003] Gerhard et al. (2002), Life spans and senescent phenotypes in two strains of Zebrafish (Danio rerio) (PubMed)
- [1094] ZFIN: The Zebrafish Model Organism Database
External Resources
- Integrated Taxonomic Information System
- ITIS 163699
- Animal Diversity Web
- ADW account
- Encyclopaedia of Life
- Search EOL
- NCBI Taxonomy
- Taxonomy ID 7955
- Entrez
- Search all databases
- Ageing Literature
- Search Google Scholar or Search PubMed
- Images
- Google Image search
- Internet
- Search Google