GenAge entry for BAK1 (Homo sapiens)

Gene name (HAGRID: 278)

HGNC symbol
BAK1 
Aliases
BCL2L7; BAK; CDN1 
Common name
BCL2-antagonist/killer 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

The BCL2 oncogene is a potent suppressor of apoptosis under diverse conditions. BAK1, a gene belonging to the BCL2 family, promotes cell death and counteracts the protection from apoptosis provided by BCL2 [2198]. Bak knockout mice showed reduced age-related apoptotic cell death of spiral ganglion neurons and hair cells in the cochlea, which in turn resulted in the prevention of age-related hearing loss [2200].

Cytogenetic information

Cytogenetic band
6p21.3
Location
33,572,546 bp to 33,580,293 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0001782; B cell homeostasis
GO:0001783; B cell apoptotic process
GO:0001836; release of cytochrome c from mitochondria
GO:0001974; blood vessel remodeling
GO:0002262; myeloid cell homeostasis
GO:0002352; B cell negative selection
GO:0006987; activation of signaling protein activity involved in unfolded protein response
GO:0007420; brain development
GO:0007568; aging
GO:0008053; mitochondrial fusion
GO:0008283; cell proliferation
And 44 more GO terms
Cellular component: GO:0005739; mitochondrion
GO:0005741; mitochondrial outer membrane
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0031307; integral component of mitochondrial outer membrane
GO:0046930; pore complex
Function: GO:0005515; protein binding
GO:0031072; heat shock protein binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0044325; ion channel binding
GO:0046872; metal ion binding
GO:0046982; protein heterodimerization activity
GO:0051087; chaperone binding
GO:0051400; BH domain binding
Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, BCL2, BAX, HSPD1, DBN1, BAK1
STRING interaction network
Protein-Protein network diagram for BAK1

Retrieve sequences for BAK1

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Mus musculus
Bak1
Rattus norvegicus
Bak1

Selected references

External links

EPD
HS_BAK1
ORF Accession
NM_001188
CDS Accession
NP_001179
OMIM
600516
HPRD
02744
Ensembl
BAK1
UniProt/Swiss-Prot
BAK_HUMAN
GeneCards
BAK1
Entrez Gene
578
UniGene
485139
GenAtlas
BAK1
Internet
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