GenAge entry for CDK7 (Homo sapiens)

Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism

Gene name (HAGRID: 299)

HGNC symbol
CDK7 
Aliases
CAK1; CDKN7; MO15; STK1; CAK 
Common name
cyclin-dependent kinase 7 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Description

CDK7 is involved in cell cycle control and RNA transcription. Cdk7 deficiency causes early embryonic lethality. However, ablation of Cdk7 in adult animals results in age-related phenotypes, including weight loss, pervasive hair-greying, kyphosis and premature death with <20% of animals living more than one year [3262]. As such, CDK7 could play some role in human ageing, although further studies are necessary to explore this hypothesis.

Cytogenetic information

Cytogenetic band
5q12.1
Location
69,234,795 bp to 69,277,430 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000079; regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082; G1/S transition of mitotic cell cycle
GO:0000086; G2/M transition of mitotic cell cycle
GO:0006283; transcription-coupled nucleotide-excision repair
GO:0006294; nucleotide-excision repair, preincision complex assembly
GO:0006361; transcription initiation from RNA polymerase I promoter
GO:0006362; transcription elongation from RNA polymerase I promoter
GO:0006363; termination of RNA polymerase I transcription
GO:0006366; transcription from RNA polymerase II promoter
GO:0006367; transcription initiation from RNA polymerase II promoter
GO:0006368; transcription elongation from RNA polymerase II promoter
GO:0006370; 7-methylguanosine mRNA capping
GO:0006468; protein phosphorylation
GO:0007050; cell cycle arrest
GO:0008283; cell proliferation
GO:0030521; androgen receptor signaling pathway
GO:0042795; snRNA transcription from RNA polymerase II promoter
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0051301; cell division
Cellular component: GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005675; holo TFIIH complex
GO:0005737; cytoplasm
GO:0005739; mitochondrion
GO:0048471; perinuclear region of cytoplasm
Function: GO:0003713; transcription coactivator activity
GO:0004672; protein kinase activity
GO:0004674; protein serine/threonine kinase activity
GO:0004693; cyclin-dependent protein serine/threonine kinase activity
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008022; protein C-terminus binding
GO:0008094; DNA-dependent ATPase activity
GO:0008353; RNA polymerase II carboxy-terminal domain kinase activity
GO:0016301; kinase activity
GO:0050681; androgen receptor binding
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, ERCC2, E2F1, BRCA1, RPA1, HSP90AA1, ERCC3, ERCC5, AR, GTF2H2, APP, A2M, CCNA2, CDK1, HDAC2, ESR1, CDK7
STRING interaction network
Protein-Protein network diagram for CDK7

Retrieve sequences for CDK7

Promoter
Promoter
ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
cdk-7
Danio rerio
cdk7
Drosophila melanogaster
Cdk7
Mus musculus
Cdk7
Rattus norvegicus
Cdk7
Saccharomyces cerevisiae
KIN28
Schizosaccharomyces pombe
crk1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as cdk-7
  • A homolog of this gene for Mus musculus is present as Cdk7

Selected references

External links

EPD
HS_CDK7_2
ORF Accession
NM_001799
CDS Accession
NP_001790
OMIM
601955
HPRD
15993
Ensembl
CDK7
UniProt/Swiss-Prot
CDK7_HUMAN
GeneCards
CDK7
Entrez Gene
1022
UniGene
184298
GenAtlas
CDK7
Internet
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