GenAge entry for DGAT1 (Homo sapiens)
Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
Gene name (HAGRID: 291)
- HGNC symbol
- DGAT1
- Aliases
- ARGP1; DGAT
- Common name
- diacylglycerol O-acyltransferase 1
Potential relevance to the human ageing process
- Main reason for selection
- Entry selected based on evidence directly linking the gene product to ageing in a mammalian model organism
- Description
DGAT1 is an enzyme involved in triglyceride synthesis and metabolism. Knockout of DGAT1 in female mice results in an extended lifespan of about 23% [3249]. As such, DGAT1 might play some role in ageing, though human studies are lacking.
Cytogenetic information
- Cytogenetic band
- 8q24.3
- Location
- 144,314,583 bp to 144,326,919 bp
- Orientation
- Minus strand
Protein information
- Gene Ontology
-
Process: GO:0006641; triglyceride metabolic process
GO:0019432; triglyceride biosynthetic process
GO:0019915; lipid storage
GO:0034379; very-low-density lipoprotein particle assembly
GO:0035336; long-chain fatty-acyl-CoA metabolic process
GO:0036155; acylglycerol acyl-chain remodeling
GO:0042572; retinol metabolic process
GO:0046339; diacylglycerol metabolic process
GO:0055089; fatty acid homeostasis
Cellular component: GO:0005789; endoplasmic reticulum membrane
GO:0016021; integral component of membrane
Show all GO termsFunction: GO:0003846; 2-acylglycerol O-acyltransferase activity
GO:0004144; diacylglycerol O-acyltransferase activity
GO:0005515; protein binding
GO:0016746; transferase activity, transferring acyl groups
GO:0050252; retinol O-fatty-acyltransferase activity
Protein interactions and network
Retrieve sequences for DGAT1
Homologs in model organisms
- Caenorhabditis elegans
- mboa-2
- Danio rerio
- dgat1b
- Mus musculus
- Dgat1
- Rattus norvegicus
- Dgat1
- Schizosaccharomyces pombe
- are1
In other databases
- GenAge model organism genes
- A homolog of this gene for Mus musculus is present as Dgat1