GenAge entry for EEF2 (Homo sapiens)

Gene name (HAGRID: 103)

HGNC symbol
EEF2 
Aliases
EEF-2; EF2 
Common name
eukaryotic translation elongation factor 2 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

EEF2 is involved in protein synthesis. Age-dependent changes to EEF2 in rats have been reported, which could account for the decline in protein synthesis in old animals [540]. EEF2 has not been directly related to human ageing.

Cytogenetic information

Cytogenetic band
19p13.3
Location
3,976,056 bp to 3,985,463 bp
Orientation
Minus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0002244; hematopoietic progenitor cell differentiation
GO:0002931; response to ischemia
GO:0003009; skeletal muscle contraction
GO:0006414; translational elongation
GO:0007568; aging
GO:0014009; glial cell proliferation
GO:0017183; peptidyl-diphthamide biosynthetic process from peptidyl-histidine
GO:0032355; response to estradiol
GO:0034976; response to endoplasmic reticulum stress
GO:0035914; skeletal muscle cell differentiation
GO:0042493; response to drug
GO:0042542; response to hydrogen peroxide
GO:0045471; response to ethanol
GO:0045727; positive regulation of translation
GO:0051593; response to folic acid
GO:0098609; cell-cell adhesion
GO:1990416; cellular response to brain-derived neurotrophic factor stimulus
GO:2000767; positive regulation of cytoplasmic translation
Cellular component: GO:0005634; nucleus
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0005886; plasma membrane
GO:0005913; cell-cell adherens junction
GO:0016020; membrane
GO:0016235; aggresome
GO:0030529; intracellular ribonucleoprotein complex
GO:0031012; extracellular matrix
GO:0042788; polysomal ribosome
GO:0045121; membrane raft
GO:0070062; extracellular exosome
Function: GO:0002039; p53 binding
GO:0003746; translation elongation factor activity
GO:0003924; GTPase activity
GO:0005515; protein binding
GO:0005525; GTP binding
GO:0008097; 5S rRNA binding
GO:0019901; protein kinase binding
GO:0043022; ribosome binding
GO:0044822; poly(A) RNA binding
GO:0051015; actin filament binding
GO:0098641; cadherin binding involved in cell-cell adhesion
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, TXN, PTEN, HSP90AA1, EP300, XRCC6, GSR, HSPD1, MAPK14, EEF1A1, ATF2, BUB1B, HSPA8, MDM2, ESR1, CDKN2A, SIRT6, MLH1
STRING interaction network
Protein-Protein network diagram for EEF2

Retrieve sequences for EEF2

ORF
ORF
CDS
CDS

Homologs in model organisms

Caenorhabditis elegans
eef-2
Danio rerio
eef2b
Drosophila melanogaster
Ef2b
Mus musculus
Eef2
Rattus norvegicus
Eef2
Saccharomyces cerevisiae
EFT1
Schizosaccharomyces pombe
eft201

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as eef-2
  • A homolog of this gene for Saccharomyces cerevisiae is present as EFT1

Selected references

External links

EPD
ORF Accession
NM_001961
CDS Accession
NP_001952
OMIM
130610
HPRD
00561
Ensembl
EEF2
UniProt/Swiss-Prot
EF2_HUMAN
GeneCards
EEF2
Entrez Gene
1938
UniGene
515070
GenAtlas
EEF2
Internet
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