GenAge entry for EGF (Homo sapiens)

Gene name (HAGRID: 48)

HGNC symbol: EGF
Aliases
Common name: epidermal growth factor

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to the regulation or control of genes previously linked to ageing
Description: EGF stimulates the growth of several epidermal and epithelial cell types. It is also involved in differentiation [366]. Expression of EGF in transgenic mice causes stunted growth [367]. An attenuation of EGF signalling has been reported with age [346], but it is unclear whether these are causes or effects of ageing.

Cytogenetic information

Cytogenetic band: 4q25
Location: 109,912,884 bp to 110,012,962 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0000186; activation of MAPKK activity
GO:0000187; activation of MAPK activity
GO:0001525; angiogenesis
GO:0002092; positive regulation of receptor internalization
GO:0002576; platelet degranulation
GO:0006260; DNA replication
GO:0007165; signal transduction
GO:0007171; activation of transmembrane receptor protein tyrosine kinase activity
GO:0007173; epidermal growth factor receptor signaling pathway
GO:0007262; STAT protein import into nucleus

And 30 more GO terms

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space
GO:0005765; lysosomal membrane
GO:0005886; plasma membrane
GO:0016021; integral component of membrane
GO:0031093; platelet alpha granule lumen
GO:0043235; receptor complex
GO:0070062; extracellular exosome

Function:

GO:0004713; protein tyrosine kinase activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005154; epidermal growth factor receptor binding
GO:0005509; calcium ion binding
GO:0005515; protein binding
GO:0008083; growth factor activity
GO:0017147; Wnt-protein binding
GO:0030297; transmembrane receptor protein tyrosine kinase activator activity
GO:0042813; Wnt-activated receptor activity
GO:0046934; phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: LMNA, EGFR, ERBB2, EGF, UBE2I, EMD, LMNB1
STRING interaction network

Retrieve sequences for EGF

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: egf
Mus musculus: Egf
Rattus norvegicus: egf

In other databases

LongevityMap

This gene is present as EGF