GenAge entry for HIF1A (Homo sapiens)

Gene name (HAGRID: 65)

HGNC symbol: HIF1A
Aliases: MOP1; HIF-1alpha; PASD8; HIF1; bHLHe78
Common name: hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: HIF1A is a transcription factor that responds to oxidative stress and oxygen [435]. Changes in HIF1A with age have been reported in rats and could be related to age-related pathologies [1593], such as neurodegeneration [1534]. Deficiencies in HIF1A have not been associated with ageing in mice [434]. Further evidence is needed to directly link HIF1A to human ageing.

Cytogenetic information

Cytogenetic band: 14q23.2
Location: 61,695,401 bp to 61,748,259 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001525; angiogenesis
GO:0001666; response to hypoxia
GO:0001755; neural crest cell migration
GO:0001837; epithelial to mesenchymal transition
GO:0001892; embryonic placenta development
GO:0001922; B-1 B cell homeostasis
GO:0001938; positive regulation of endothelial cell proliferation
GO:0001947; heart looping
GO:0002052; positive regulation of neuroblast proliferation
GO:0002248; connective tissue replacement involved in inflammatory response wound healing
GO:0003151; outflow tract morphogenesis
GO:0003208; cardiac ventricle morphogenesis
GO:0006089; lactate metabolic process
GO:0006355; regulation of transcription, DNA-templated
GO:0006366; transcription from RNA polymerase II promoter
GO:0006879; cellular iron ion homeostasis
GO:0007165; signal transduction
GO:0007595; lactation
GO:0008542; visual learning
GO:0010468; regulation of gene expression
GO:0010573; vascular endothelial growth factor production
GO:0010575; positive regulation of vascular endothelial growth factor production
GO:0010628; positive regulation of gene expression
GO:0010634; positive regulation of epithelial cell migration
GO:0010870; positive regulation of receptor biosynthetic process
GO:0014850; response to muscle activity
GO:0016239; positive regulation of macroautophagy
GO:0019896; axonal transport of mitochondrion
GO:0021502; neural fold elevation formation
GO:0021987; cerebral cortex development
GO:0030502; negative regulation of bone mineralization
GO:0030949; positive regulation of vascular endothelial growth factor receptor signaling pathway
GO:0032007; negative regulation of TOR signaling
GO:0032364; oxygen homeostasis
GO:0032722; positive regulation of chemokine production
GO:0032909; regulation of transforming growth factor beta2 production
GO:0032963; collagen metabolic process
GO:0035162; embryonic hemopoiesis
GO:0035774; positive regulation of insulin secretion involved in cellular response to glucose stimulus
GO:0042541; hemoglobin biosynthetic process
GO:0042593; glucose homeostasis
GO:0042789; mRNA transcription from RNA polymerase II promoter
GO:0043619; regulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045648; positive regulation of erythrocyte differentiation
GO:0045766; positive regulation of angiogenesis
GO:0045821; positive regulation of glycolytic process
GO:0045893; positive regulation of transcription, DNA-templated
GO:0045926; negative regulation of growth
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0046716; muscle cell cellular homeostasis
GO:0046886; positive regulation of hormone biosynthetic process
GO:0048546; digestive tract morphogenesis
GO:0051000; positive regulation of nitric-oxide synthase activity
GO:0051216; cartilage development
GO:0051541; elastin metabolic process
GO:0060574; intestinal epithelial cell maturation
GO:0061030; epithelial cell differentiation involved in mammary gland alveolus development
GO:0061072; iris morphogenesis
GO:0061298; retina vasculature development in camera-type eye
GO:0061418; regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061419; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070101; positive regulation of chemokine-mediated signaling pathway
GO:0070244; negative regulation of thymocyte apoptotic process
GO:0071347; cellular response to interleukin-1
GO:0071456; cellular response to hypoxia
GO:0071542; dopaminergic neuron differentiation
GO:0097411; hypoxia-inducible factor-1alpha signaling pathway
GO:1902895; positive regulation of pri-miRNA transcription from RNA polymerase II promoter
GO:1903377; negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
GO:1903599; positive regulation of mitophagy
GO:1903715; regulation of aerobic respiration
GO:2000378; negative regulation of reactive oxygen species metabolic process
GO:2001054; negative regulation of mesenchymal cell apoptotic process

Cellular component:

GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005667; transcription factor complex
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0016607; nuclear speck
GO:0031514; motile cilium
GO:0090575; RNA polymerase II transcription factor complex
GO:1904115; axon cytoplasm

Function:

GO:0000989; transcription factor activity, transcription factor binding
GO:0001076; transcription factor activity, RNA polymerase II transcription factor binding
GO:0001077; transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001228; transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003705; transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
GO:0005515; protein binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding
GO:0019901; protein kinase binding
GO:0031625; ubiquitin protein ligase binding
GO:0035035; histone acetyltransferase binding
GO:0035257; nuclear hormone receptor binding
GO:0042826; histone deacetylase binding
GO:0043565; sequence-specific DNA binding
GO:0046982; protein heterodimerization activity
GO:0051879; Hsp90 protein binding
GO:0070888; E-box binding

Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, TP53, ATM, STAT3, HDAC3, MYC, PARP1, BRCA1, CREBBP, BCL2, VCP, HSP90AA1, UBE2I, EP300, RB1, RELA, HDAC1, SP1, JUN, APEX1, HSPA8, SIN3A, HDAC2, MAX, MDM2, ESR1, CTNNB1, CDKN2A, STUB1, ARNTL, SQSTM1
STRING interaction network

Retrieve sequences for HIF1A

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: hif1ab
Mus musculus: Hif1a
Rattus norvegicus: Hif1a

In other databases

LongevityMap

This gene is present as HIF1A

CellAge

This gene is present as HIF1A