GenAge entry for CTNNB1 (Homo sapiens)

Gene name (HAGRID: 223)

HGNC symbol: CTNNB1
Aliases: beta-catenin; armadillo; CTNNB
Common name: catenin (cadherin-associated protein), beta 1, 88kDa

Potential relevance to the human ageing process

Main reason for selection

Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing

Description

CTNNB1, also known as beta-catenin, is a member of the adherens junctions proteins, involved in epithelial layers that mediate adhesion between cells, cell communication, growth, embryogenesis, and wound healing.

In roundworms, CTNNB1 has been associated with FOXO in oxidative stress signalling [1358]. In mice with a conditional mutation in CTNNB1 in the epidermis and hair follicles, if CTNNB1 was deleted, hair was completely lost after the first hair cycle, and without CTNNB1 skin stem cells failed to differentiate [1359]. CTNNB1 is also involved in Wnt signalling, which could play a role in adult stem cell self-renewal [1364]. Engraftment of young haematopoietic cells into old mice reverses the aged fracture phenotype and diminished osteoblastic differentiation capacity of old mice. CTNNB1 signalling was found to be important in this process. Temporal reduction of CTNNB1 during early fracture repair has been found to improve bone healing in old mice [4334].

Mutations in CTNNB1 have been associated with cancer in human patients [1362]. A role for CTNNB1 in human ageing is plausible though unconfirmed.

Cytogenetic information

Cytogenetic band: 3p21
Location: 41,199,451 bp to 41,240,448 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000578; embryonic axis specification
GO:0000904; cell morphogenesis involved in differentiation
GO:0001569; branching involved in blood vessel morphogenesis
GO:0001658; branching involved in ureteric bud morphogenesis
GO:0001701; in utero embryonic development
GO:0001702; gastrulation with mouth forming second
GO:0001708; cell fate specification
GO:0001711; endodermal cell fate commitment
GO:0001764; neuron migration
GO:0001837; epithelial to mesenchymal transition

And 127 more GO terms

Cellular component:	GO:0000922; spindle pole GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005667; transcription factor complex GO:0005719; nuclear euchromatin GO:0005737; cytoplasm GO:0005813; centrosome GO:0005829; cytosol GO:0005886; plasma membrane GO:0005911; cell-cell junction GO:0005912; adherens junction
	And 26 more GO terms

Function:

GO:0001085; RNA polymerase II transcription factor binding
GO:0001102; RNA polymerase II activating transcription factor binding
GO:0003682; chromatin binding
GO:0003690; double-stranded DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0003713; transcription coactivator activity
GO:0004871; signal transducer activity
GO:0005515; protein binding
GO:0008022; protein C-terminus binding
GO:0008134; transcription factor binding
GO:0019899; enzyme binding

And 16 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: PROP1, LMNA, PTPN11, PTPN1, AKT1, EGFR, ERBB2, PARP1, BRCA1, PIN1, PTEN, CREBBP, HIF1A, EGR1, ABL1, TOP2A, NFKB1, EP300, PML, GSK3B, HTT, PRKCA, AR, HSPA8, EMD, FOXO3, FOXM1, UCHL1, APP, SIRT1, HDAC1, HSPA1B, MAPK8, YWHAZ, FGFR1, SP1, MAPK9, CCNA2, FAS, LMNB1, FOXO4, PIK3R1, TFAP2A, CREB1, ATF2, PTGS2, ESR1, PSEN1, PPARG, GSK3A, IKBKB
STRING interaction network

Retrieve sequences for CTNNB1

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ctnnb1
Drosophila melanogaster: arm
Mus musculus: Ctnnb1
Rattus norvegicus: Ctnnb1

In other databases

CellAge

This gene is present as CTNNB1