GenAge entry for NOG (Homo sapiens)

Gene name (HAGRID: 229)

HGNC symbol: NOG
Aliases: SYNS1; SYM1
Common name: noggin

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description: NOG appears to be involved in development, though its exact functions remain unclear. Mice without NOG die shortly after birth [1417]. Overexpression of NOG in mice resulted in severe osteoporosis [1412]. Mutations in the human NOG gene affect joint morphogenesis [1415]. NOG may be a factor in bone ageing, but its role in human ageing remains to be established.

Cytogenetic information

Cytogenetic band: 17q22
Location: 56,593,699 bp to 56,595,590 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001501; skeletal system development
GO:0001649; osteoblast differentiation
GO:0001701; in utero embryonic development
GO:0001706; endoderm formation
GO:0001707; mesoderm formation
GO:0001837; epithelial to mesenchymal transition
GO:0001839; neural plate morphogenesis
GO:0001843; neural tube closure
GO:0003149; membranous septum morphogenesis
GO:0003151; outflow tract morphogenesis

And 48 more GO terms

Cellular component:

GO:0005576; extracellular region
GO:0005615; extracellular space

Function:

GO:0005515; protein binding
GO:0019955; cytokine binding
GO:0042803; protein homodimerization activity

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: NOG
STRING interaction network

Retrieve sequences for NOG

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: nog1
Mus musculus: Nog
Rattus norvegicus: Nog