GenAge entry for PTK2 (Homo sapiens)

Gene name (HAGRID: 166)

HGNC symbol: PTK2
Aliases: FAK; FADK; FAK1; PPP1R71
Common name: protein tyrosine kinase 2

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: PTK2, also known as focal adhesion kinase (FAK), plays a role in the signal transduction of a number of pathways such as MAPK signalling, apoptosis, cellular proliferation, and cellular senescence [998]. PTK2 deletion in the epidermis of mice suppresses tumour formation [1717]. Its role, if any, in human ageing is unknown, but PTK2 could potentially be involved in downstream signalling cascades related to ageing.

Cytogenetic information

Cytogenetic band: 8q24.3
Location: 140,658,382 bp to 141,001,313 bp
Orientation: Minus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000165; MAPK cascade
GO:0000226; microtubule cytoskeleton organization
GO:0001525; angiogenesis
GO:0001570; vasculogenesis
GO:0001764; neuron migration
GO:0001890; placenta development
GO:0001932; regulation of protein phosphorylation
GO:0001934; positive regulation of protein phosphorylation
GO:0003007; heart morphogenesis
GO:0006921; cellular component disassembly involved in execution phase of apoptosis
GO:0007172; signal complex assembly

And 45 more GO terms

Cellular component:	GO:0001725; stress fiber GO:0005634; nucleus GO:0005737; cytoplasm GO:0005815; microtubule organizing center GO:0005829; cytosol GO:0005856; cytoskeleton GO:0005886; plasma membrane GO:0005925; focal adhesion GO:0005938; cell cortex GO:0016324; apical plasma membrane GO:0030027; lamellipodium
	And 2 more GO terms

Function:

GO:0003779; actin binding
GO:0004672; protein kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0004871; signal transducer activity
GO:0005088; Ras guanyl-nucleotide exchange factor activity
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0008432; JUN kinase binding
GO:0019901; protein kinase binding

And 2 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, TP53, IGF1R, PTPN11, STAT3, IRS1, EGFR, ERBB2, RET, PARP1, PTEN, HSP90AA1, GSK3B, GRB2, APP, PTK2, PIK3R1, MDM2, JAK2, PPP1CA, STUB1, SOCS2
STRING interaction network

Retrieve sequences for PTK2

ORF: ORF
CDS: CDS

Homologs in model organisms

Danio rerio: ptk2.1
Mus musculus: Ptk2
Rattus norvegicus: Ptk2

In other databases

CellAge

This gene is present as PTK2