GenAge entry for PTK2B (Homo sapiens)

Gene name (HAGRID: 165)

HGNC symbol: PTK2B
Aliases: CAKB; PYK2; RAFTK; PTK; CADTK; FAK2
Common name: protein tyrosine kinase 2 beta

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence showing that the gene product to be a target of genes previously linked to ageing
Description: Involved in stress response and signal transduction, PTK2B is an important player in a variety of processes including the regulation of ion channels by calcium and MAPK signalling [769]. PTK2B is a focal adhesion kinase (FAK), which could be involved in cellular senescence and apoptosis [1716]. Its role, if any, in human ageing is unknown, but PTK2B could potentially be involved in downstream signalling cascades related to ageing.

Cytogenetic information

Cytogenetic band: 8p21.1
Location: 27,311,482 bp to 27,459,391 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:	GO:0000165; MAPK cascade GO:0001525; angiogenesis GO:0001556; oocyte maturation GO:0001666; response to hypoxia GO:0001954; positive regulation of cell-matrix adhesion GO:0002040; sprouting angiogenesis GO:0002250; adaptive immune response GO:0002315; marginal zone B cell differentiation GO:0006461; protein complex assembly GO:0006468; protein phosphorylation GO:0006915; apoptotic process
	And 81 more GO terms

Cellular component:	GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005737; cytoplasm GO:0005829; cytosol GO:0005856; cytoskeleton GO:0005925; focal adhesion GO:0005938; cell cortex GO:0014069; postsynaptic density GO:0017146; NMDA selective glutamate receptor complex GO:0030027; lamellipodium GO:0030424; axon
	And 9 more GO terms

Function:

GO:0004683; calmodulin-dependent protein kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0004871; signal transducer activity
GO:0004972; NMDA glutamate receptor activity
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding
GO:0032403; protein complex binding
GO:0043423; 3-phosphoinositide-dependent protein kinase binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: PTPN11, IL7R, EGFR, ERBB2, PRKCD, PTEN, HSP90AA1, GRB2, PTK2B, MAPT, JAK2, SOCS2
STRING interaction network

Retrieve sequences for PTK2B

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: kin-32
Danio rerio: ptk2bb
Drosophila melanogaster: Fak
Mus musculus: Ptk2b
Rattus norvegicus: Ptk2b