GenAge entry for SQSTM1 (Homo sapiens)

Gene name (HAGRID: 298)

HGNC symbol
SQSTM1 
Aliases
p62; p60; p62B; A170; PDB3; OSIL 
Common name
sequestosome 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on indirect or inconclusive evidence linking the gene product to ageing in humans or in one or more model systems
Description

SQSTM1 is involved in autophagic degradation, but possibly apoptosis, immune response and other functions. SQSTM1 knockout mice are short-lived, perhaps due to its role in activating NFE2L2 since tissues exhibited a pro-oxidative environment due to compromised mitochondrial electron transport. Males live 34% less, while females are only slightly shorter-lived. Males also exhibit some signs of accelerated ageing [3261]. While its role in ageing is unproven, SQSTM1 is worthy of further studies.

Cytogenetic information

Cytogenetic band
5q35
Location
179,806,387 bp to 179,838,077 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0000422; mitophagy
GO:0001934; positive regulation of protein phosphorylation
GO:0002376; immune system process
GO:0006468; protein phosphorylation
GO:0006511; ubiquitin-dependent protein catabolic process
GO:0006914; autophagy
GO:0006915; apoptotic process
GO:0006950; response to stress
GO:0008104; protein localization
GO:0010821; regulation of mitochondrion organization
GO:0016197; endosomal transport
GO:0016236; macroautophagy
GO:0016239; positive regulation of macroautophagy
GO:0030154; cell differentiation
GO:0035556; intracellular signal transduction
GO:0043065; positive regulation of apoptotic process
GO:0043066; negative regulation of apoptotic process
GO:0043122; regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044130; negative regulation of growth of symbiont in host
GO:0045944; positive regulation of transcription from RNA polymerase II promoter
GO:0046578; regulation of Ras protein signal transduction
GO:0051291; protein heterooligomerization
GO:0061635; regulation of protein complex stability
GO:0098779; mitophagy in response to mitochondrial depolarization
Cellular component: GO:0000407; pre-autophagosomal structure
GO:0000932; P-body
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005770; late endosome
GO:0005776; autophagosome
GO:0005783; endoplasmic reticulum
GO:0005829; cytosol
GO:0016234; inclusion body
GO:0016235; aggresome
GO:0016605; PML body
GO:0044753; amphisome
GO:0044754; autolysosome
GO:0070062; extracellular exosome
GO:0097225; sperm midpiece
Function: GO:0004674; protein serine/threonine kinase activity
GO:0005080; protein kinase C binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0019901; protein kinase binding
GO:0030971; receptor tyrosine kinase binding
GO:0031625; ubiquitin protein ligase binding
GO:0042169; SH2 domain binding
GO:0042802; identical protein binding
GO:0042803; protein homodimerization activity
GO:0043130; ubiquitin binding
GO:0070530; K63-linked polyubiquitin binding
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TP53, STAT5A, NGFR, MYC, INSR, NCOR1, PRKCD, PEX5, HIF1A, BCL2, PML, HTT, FAS, YWHAZ, MAPK14, PIK3R1, CDK1, MAPT, MTOR, MLH1, STUB1, PCK1, NFE2L2, PIK3CA, SQSTM1
STRING interaction network
Protein-Protein network diagram for SQSTM1

Retrieve sequences for SQSTM1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
sqstm1
Mus musculus
Sqstm1
Rattus norvegicus
Sqstm1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Sqstm1

Selected references

External links

EPD
ORF Accession
NM_001142298
CDS Accession
NP_001135770
OMIM
601530
HPRD
03319
Ensembl
SQSTM1
UniProt/Swiss-Prot
SQSTM_HUMAN
GeneCards
SQSTM1
Entrez Gene
8878
UniGene
724025
GenAtlas
SQSTM1
Internet
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