GenAge entry for PML (Homo sapiens)

Gene name (HAGRID: 96)

HGNC symbol: PML
Aliases: MYL; TRIM19; RNF71
Common name: promyelocytic leukemia

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a cellular model system
Description: The PML gene encodes a number of transcripts and can function as a transcription factor. It is likely oncogenic and may act as a tumour suppressor [518]. PML also appears to control cell proliferation and cellular senescence [517], though its role, if any, in human ageing is unknown.

Cytogenetic information

Cytogenetic band: 15q22
Location: 73,994,673 bp to 74,047,814 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001666; response to hypoxia
GO:0001932; regulation of protein phosphorylation
GO:0006351; transcription, DNA-templated
GO:0006355; regulation of transcription, DNA-templated
GO:0006461; protein complex assembly
GO:0006919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0006977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007050; cell cycle arrest
GO:0007179; transforming growth factor beta receptor signaling pathway
GO:0007182; common-partner SMAD protein phosphorylation
GO:0007184; SMAD protein import into nucleus

And 42 more GO terms

Cellular component:	GO:0000784; nuclear chromosome, telomeric region GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005730; nucleolus GO:0005737; cytoplasm GO:0005829; cytosol GO:0016363; nuclear matrix GO:0016605; PML body GO:0031901; early endosome membrane GO:0031965; nuclear membrane GO:0042406; extrinsic component of endoplasmic reticulum membrane
	And 1 more GO terms

Function:

GO:0003677; DNA binding
GO:0005515; protein binding
GO:0008270; zinc ion binding
GO:0031625; ubiquitin protein ligase binding
GO:0032183; SUMO binding
GO:0042803; protein homodimerization activity
GO:0046332; SMAD binding

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: TP53, TERT, WRN, LMNA, STAT3, MYC, EGFR, FOS, HDAC3, PIN1, CREBBP, NCOR1, BCL2, TOP2B, NFKB1, RAD51, UBE2I, PML, HTT, RB1, FOXO1, SIRT1, HDAC1, SP1, JUN, MAPK3, FAS, ATF2, SIN3A, CDK1, HDAC2, MDM2, RELA, SUMO1, H2AFX, NR3C1, MTOR, CTNNB1, CDKN2A, TP63, CHEK2, PPARGC1A, PPARG, NCOR2, SQSTM1
STRING interaction network

Retrieve sequences for PML

ORF: ORF
CDS: CDS

Homologs in model organisms

Mus musculus: Pml
Rattus norvegicus: Pml

In other databases

CellAge

This gene is present as PML