GenAge entry for TERF1 (Homo sapiens)

Gene name (HAGRID: 105)

HGNC symbol
TERF1 
Aliases
PIN2; TRF1; TRF; TRBF1 
Common name
telomeric repeat binding factor (NIMA-interacting) 1 

Potential relevance to the human ageing process

Main reason for selection
Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description

TERF1 associates with the telomeres and appears to be an important regulator of telomere biology [73]. Expression of TERF1 in mice prevented age-related decline in neuromuscular function, glucose homeostasis, cognitive function, lipid stores, and chronic anemia [4503]. Though, its role in human ageing is unknown, TERF1 levels decrease with ageing in both mice and humans.

Cytogenetic information

Cytogenetic band
8q21.11
Location
73,008,862 bp to 73,047,752 bp
Orientation
Plus strand
Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology
Process: GO:0000723; telomere maintenance
GO:0007004; telomere maintenance via telomerase
GO:0007067; mitotic nuclear division
GO:0008156; negative regulation of DNA replication
GO:0016233; telomere capping
GO:0031627; telomeric loop formation
GO:0032211; negative regulation of telomere maintenance via telomerase
GO:0032214; negative regulation of telomere maintenance via semi-conservative replication
GO:0042493; response to drug
GO:0045141; meiotic telomere clustering
GO:0051301; cell division
GO:0051974; negative regulation of telomerase activity
GO:1904792; positive regulation of telosome assembly
GO:1904850; negative regulation of establishment of protein localization to telomere
GO:1904911; negative regulation of establishment of RNA localization to telomere
GO:1904914; negative regulation of establishment of macromolecular complex localization to telomere
Cellular component: GO:0000783; nuclear telomere cap complex
GO:0000784; nuclear chromosome, telomeric region
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005730; nucleolus
GO:0005737; cytoplasm
GO:0005819; spindle
GO:0070187; telosome
Function: GO:0003677; DNA binding
GO:0003691; double-stranded telomeric DNA binding
GO:0003720; telomerase activity
GO:0005515; protein binding
GO:0008301; DNA binding, bending
GO:0042162; telomeric DNA binding
GO:0042803; protein homodimerization activity
GO:0043130; ubiquitin binding
GO:0098505; G-rich strand telomeric DNA binding
Hide GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge
TERT, ATM, NBN, BRCA1, BLM, HSP90AA1, ABL1, EP300, TERF1, PRKDC, XRCC5, FEN1, TERF2, RECQL4, FOXM1, SNCG, PRDX1, GSS, PCMT1, APEX1, MTOR, DBN1, STUB1
STRING interaction network
Protein-Protein network diagram for TERF1

Retrieve sequences for TERF1

ORF
ORF
CDS
CDS

Homologs in model organisms

Danio rerio
terf1
Mus musculus
Terf1
Rattus norvegicus
Terf1

In other databases

LongevityMap
  • This gene is present as TERF1

Selected references

External links

EPD
ORF Accession
NM_017489
CDS Accession
NP_059523
OMIM
600951
HPRD
02975
Ensembl
TERF1
UniProt/Swiss-Prot
TERF1_HUMAN
GeneCards
TERF1
Entrez Gene
7013
UniGene
442707
GenAtlas
TERF1
Internet
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