GenAge entry for ABL1 (Homo sapiens)

Gene name (HAGRID: 78)

HGNC symbol: ABL1
Aliases: JTK7; c-ABL; p150; ABL
Common name: ABL proto-oncogene 1, non-receptor tyrosine kinase

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence linking the gene product to a pathway or mechanism linked to ageing
Description: An important player in cellular proliferation and development, ABL1 also acts as an oncogene [471]. Some results indicate ABL1 might also be involved in DNA repair [474]. Disruption of ABL1 in mice results in severe defects and animals die shortly after birth [472]. Although its exact functions remain elusive, ABL1 has been argued to play a role in ageing due to its interaction with ageing-related genes, such as ATM, and its functions [1292].

Cytogenetic information

Cytogenetic band: 9q34.1
Location: 130,713,881 bp to 130,887,675 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0001922; B-1 B cell homeostasis
GO:0001934; positive regulation of protein phosphorylation
GO:0002322; B cell proliferation involved in immune response
GO:0002333; transitional one stage B cell differentiation
GO:0006298; mismatch repair
GO:0006355; regulation of transcription, DNA-templated
GO:0006464; cellular protein modification process
GO:0006914; autophagy
GO:0006974; cellular response to DNA damage stimulus
GO:0006975; DNA damage induced protein phosphorylation
GO:0006979; response to oxidative stress

And 69 more GO terms

Cellular component:	GO:0005634; nucleus GO:0005654; nucleoplasm GO:0005730; nucleolus GO:0005737; cytoplasm GO:0005739; mitochondrion GO:0005829; cytosol GO:0015629; actin cytoskeleton GO:0031234; extrinsic component of cytoplasmic side of plasma membrane GO:0031252; cell leading edge GO:0031965; nuclear membrane GO:0048471; perinuclear region of cytoplasm
	And 1 more GO terms

Function:

GO:0000287; magnesium ion binding
GO:0003677; DNA binding
GO:0003785; actin monomer binding
GO:0004515; nicotinate-nucleotide adenylyltransferase activity
GO:0004672; protein kinase activity
GO:0004713; protein tyrosine kinase activity
GO:0004715; non-membrane spanning protein tyrosine kinase activity
GO:0005080; protein kinase C binding
GO:0005102; receptor binding
GO:0005515; protein binding
GO:0005524; ATP binding

And 8 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: SHC1, TP53, ATM, EGFR, ERBB2, FOS, PARP1, BRCA1, HSP90AA1, ABL1, RAD51, TERF1, PRKDC, CAT, PCNA, XRCC6, HSPA8, RB1, GRB2, PRDX1, GPX1, HSPD1, YWHAZ, JUN, PIK3R1, CREB1, CDK1, MDM2, NFKBIA, MTOR, CTNNB1, MAPT, ATR, STUB1, TP73
STRING interaction network

Retrieve sequences for ABL1

Promoter: Promoter
ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: abl-1
Danio rerio: abl1
Drosophila melanogaster: Abl
Mus musculus: Abl1
Rattus norvegicus: Abl1