Cell Senescence Entries for ORC1

Cell Types
Retinal pigment epithelial
Cell Lines
HTERT-RPE1
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
McKinley et al. (2017) Large-Scale Analysis of CRISPR/Cas9 Cell-Cycle Knockouts Reveals the Diversity of p53-Dependent Responses to Cell-Cycle Defects. Dev Cell 40(4)405-420.e2 (PubMed)

ORC1 Gene Information

HGNC symbol
ORC1 
Aliases
HSORC1; ORC1L; PARC1 
Common name
origin recognition complex subunit 1 
Entrez Id
4998
Description
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is the largest subunit of the ORC complex. While other ORC subunits are stable throughout the cell cycle, the levels of this protein vary during the cell cycle, which has been shown to be controlled by ubiquitin-mediated proteolysis after initiation of DNA replication. This protein is found to be selectively phosphorylated during mitosis. It is also reported to interact with MYST histone acetyltransferase 2 (MyST2/HBO1), a protein involved in control of transcription silencing. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010].

ORC1 Ontologies

Gene Ontology
Process: GO:6260; DNA replication
GO:6270; DNA replication initiation
GO:33314; mitotic DNA replication checkpoint signaling
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:808; origin recognition complex
GO:5664; nuclear origin of replication recognition complex
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3677; DNA binding
GO:5515; protein binding
GO:16887; ATP hydrolysis activity
GO:3682; chromatin binding
GO:3688; DNA replication origin binding
Show all GO terms

Homologs of ORC1 in Model Organisms

Caenorhabditis elegans
orc-1
Danio rerio
orc1
Drosophila melanogaster
Orc1
Mus musculus
Orc1
Rattus norvegicus
Orc1
Schizosaccharomyces pombe
orc1

In other databases

CellAge gene expression
  • This gene is present as ORC1

External links

OMIM
601902
Ensembl
ENSG00000085840
Entrez Gene
4998
UniGene
17908
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ORC1
GeneCards
ORC1