CellAge Database of Cell Senescence Genes
Cell senescence can be defined as the irreversible cessation of cell division of normally proliferating cells. Human cells become senescent from progressive shortening of telomeres as cells divide, stress or oncogenes. Primarily an anti-tumour mechanism, senescent cells accumulate with age in tissues and have been associated with degeneration and ageing of whole organisms. Many proteins have been linked to cell senescence as biomarkers and as causal drivers. To facilitate studies focused on cell senescence, we developed CellAge, a database of genes associated with cell senescence. Our manually-curated data is based on gene manipulation experiments in different human cell types. A gene expression signature of cellular senescence is also available. By integrating these and other datasets we performed a systems biology analysis of cell senescence.
Finding Entries in CellAge
Searching and browsing the full dataset is simple and intuitive. Just type your search query to filter the data, such as by using a gene name or HGNC symbol, or perhaps the name of a cell type. Note that the search is case insensitive.
A summary of the database, such as genes and cell lines available, is made available via the CellAge statistics page.
Downloading CellAge
You can download all genes associated with cell senescence as a CSV file. You can also download the gene expression signatures as a CSV file.
CellAge Release Notes
Release notes for the current build are available here.
Conditions of Use, Credits, and Feedback
CellAge is made freely available to everyone under the terms and conditions described in HAGR's license. Available are also the image credits.
If you find an error or wish to propose additional data, please contact us. To receive the latest CellAge news and announcements, such as notification when new builds are released, please join the HAGR-news mailing list.