Cell Senescence Entries for PSMD14

Cell Types
Breast cancer, Cervical cancer, Colorectal cancer, Glioma, Lung cancer, Melanoma, Ovarian cancer, Pancreatic cancer, Prostate cancer
Cell Lines
A427, A549, BTS49-SK-OV-3, DU145, HCC1937, HCT116, HeLa, MIA PaCa-2, NCI-H1299, NCI-H23, NCI-H460, NCI-H522, SK-BR-3, SK-LU-1, SK-MEL-2, SNB-75
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Byrne et al. (2010) Knockdown of human deubiquitinase PSMD14 induces cell cycle arrest and senescence. Exp Cell Res 316(2)258-71 (PubMed)

PSMD14 Gene Information

HGNC symbol
PSMD14 
Aliases
pad1; POH1; Rpn11 
Common name
proteasome 26S subunit, non-ATPase 14 
Entrez Id
10213
Description
This gene encodes a component of the 26S proteasome. The 26S proteasome is a large multiprotein complex that catalyzes the degradation of ubiquitinated intracellular proteins. The encoded protein is a component of the 19S regulatory cap complex of the 26S proteasome and mediates substrate deubiquitination. A pseudogene of this gene is also located on the long arm of chromosome 2. [provided by RefSeq, Feb 2012].

PSMD14 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:6511; ubiquitin-dependent protein catabolic process
GO:10950; positive regulation of endopeptidase activity
GO:45471; response to ethanol
GO:70536; protein K63-linked deubiquitination
GO:16579; protein deubiquitination
GO:43161; proteasome-mediated ubiquitin-dependent protein catabolic process
GO:724; double-strand break repair via homologous recombination
GO:6303; double-strand break repair via nonhomologous end joining
And 2 more GO terms
Cellular component: GO:5634; nucleus
GO:502; proteasome complex
GO:5576; extracellular region
GO:22624; proteasome accessory complex
GO:31597; cytosolic proteasome complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
GO:8541; proteasome regulatory particle, lid subcomplex
Function: GO:46872; metal ion binding
GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:5515; protein binding
GO:8237; metallopeptidase activity
GO:70122; isopeptidase activity
GO:140492; metal-dependent deubiquitinase activity
GO:61578; Lys63-specific deubiquitinase activity
GO:4843; thiol-dependent deubiquitinase
GO:61133; endopeptidase activator activity
GO:70628; proteasome binding
And 1 more GO terms
Show all GO terms

Homologs of PSMD14 in Model Organisms

Caenorhabditis elegans
rpn-11
Danio rerio
psmd14
Drosophila melanogaster
Rpn11
Mus musculus
Psmd14
Rattus norvegicus
Psmd14
Saccharomyces cerevisiae
RPN11
Schizosaccharomyces pombe
rpn11

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as rpn-11

External links

OMIM
607173
Ensembl
ENSG00000115233
Entrez Gene
10213
UniGene
740477
1000 Genomes
1000 Genomes
HPRD
GenAtlas
PSMD14
GeneCards
PSMD14