GenDR Dietary Restriction Gene Manipulation: Sir2
Gene Information (Entrez Gene ID: 34708)
- Symbol
- Sir2
- Aliases
- BEST:LD38188 CG5216 D.mel1 Dmel\CG5216 dmSRT406 dsir2 dSir2 dSIR2 DSir2 l(2)05326 sir2 SIR2 Sir2L
- Name
- Protein Sir2
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 34708
Potential relevance to dietary restriction and ageing
- Observations
-
Overexpression of Sir2 (alias dSir2) extends lifespan by up to 57% and specifically median lifespan by 40-60%, whereas a decrease in Sir2 activity by mutation blocks the life-extending effect of DR. Sir2 mutation does not reduce lifespan under ad libitum [1284]. Another study also found that whole-body Sir2 knockdown suppressed the life-extending effects of DR; moreover, Sir2 knockdown in the fat body resulted in suppression of life-extension under yeast-restricted conditions but normal lifespan under normal diet [2622].
- References
-
- [2622] Banerjee et al. (2012) "dSir2 in the adult fat body, but not in muscles, regulates life span in a diet-dependent manner." Cell Rep 2(6):1485-1491 (PubMed)
- [1284] Rogina and Helfand (2004) "Sir2 mediates longevity in the fly through a pathway related to calorie restriction." Proc. Natl. Acad. Sci. U.S.A. 101(45):15998-16003 (PubMed)
In other databases
- GenAge model organism genes
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as SIRT1
- GenDR gene manipulations
- A homolog of this gene for Mus musculus is present as Sirt1
- LongevityMap
- A homolog of this gene for Homo sapiens is present as SIRT1
- CellAge
- A homolog of this gene for Homo sapiens is present as SIRT1
Homologs
External links
- FlyBase
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- Ensembl
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- Entrez Gene
- ID 34708
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar