Cell Senescence Entries for SIRT1
- Cell Types
- Lung fibroblast
- Cell Lines
- 2BS
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Huang et al. (2008) SIRT1 overexpression antagonizes cellular senescence with activated ERK/S6k1 signaling in human diploid fibroblasts. PLoS One 3(3)e1710 (PubMed)
SIRT1 Gene Information
- HGNC symbol
- SIRT1
- Aliases
- SIR2L1
- Common name
- sirtuin 1
- Entrez Id
- 23411
- Description
- This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008].
SIRT1 Ontologies
- Gene Ontology
-
Process: GO:2000773; negative regulation of cellular senescence
GO:43066; negative regulation of apoptotic process
GO:16567; protein ubiquitination
GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:122; negative regulation of transcription by RNA polymerase II
GO:720; pyrimidine dimer repair by nucleotide-excision repair
GO:731; DNA synthesis involved in DNA repair
GO:1525; angiogenesis
GO:1542; ovulation from ovarian follicle
And 114 more GO terms Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:1650; fibrillar center
GO:5739; mitochondrion
GO:785; chromatin
GO:792; heterochromatin
GO:32991; protein-containing complex
GO:5637; nuclear inner membrane
GO:16605; PML body
And 8 more GO terms
Show all GO termsFunction: GO:5515; protein binding
GO:46872; metal ion binding
GO:16740; transferase activity
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:2039; p53 binding
GO:3713; transcription coactivator activity
GO:3714; transcription corepressor activity
GO:17136; NAD-dependent histone deacetylase activity
GO:19213; deacetylase activity
GO:19899; enzyme binding
GO:19904; protein domain specific binding
And 17 more GO terms
Homologs of SIRT1 in Model Organisms
- Caenorhabditis elegans
- sir-2.1
- Danio rerio
- sirt1
- Drosophila melanogaster
- Sir2
- Mus musculus
- Sirt1
- Rattus norvegicus
- Sirt1
In other databases
- GenAge model organism genes
- GenAge human genes
- This gene is present as SIRT1
- GenDR gene manipulations
- LongevityMap
- This gene is present as SIRT1
External links
- OMIM
- 604479
- Ensembl
- ENSG00000096717
- Entrez Gene
- 23411
- UniGene
- 369779
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- SIRT1
- GeneCards
- SIRT1