GenDR Dietary Restriction Gene Manipulation: foxo
Gene Information (Entrez Gene ID: 41709)
- Symbol
- foxo
- Aliases
- 3143 Afx anon-WO0118547.374 cg3143 CG3143 dfoxo dFoxo dFoxO dFOXO Dfoxo Dmel\CG3143 DmQ95V5 fd88A FKHR foxO Foxo FoxO FOXO foxo|dFOXO Q95V55
- Name
- Forkhead box, sub-group O
- Organism
- Drosophila melanogaster (AnAge)
- Entrez Gene ID
- 41709
Potential relevance to dietary restriction and ageing
- Observations
-
foxo overexpression extends lifespan. Activation of foxo in the adult pericerebral fat body is sufficient for lifespan extension. Limited activation of foxo reduces the expression of Drosophila insulin-like peptide dilp-2 synthesised in neurons and, represses endogenous insulin-dependent signalling in peripheral fat body [1091]. foxo is not required for DR, but its activity modulates the response. foxo null mutants are shorter-lived than wild-type on all food dilutions apart from 0.1 SY and under starvation. foxo overexpression in adult fat body under normal nutrition leads to extension of lifespan of females and causes an attenuated lifespan response to DR [2578].
- References
-
In other databases
- GenAge model organism genes
- This gene is present as foxo
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as FOXO4
- GenDR gene manipulations
- A homolog of this gene for Mus musculus is present as Foxo3
- LongevityMap
- A homolog of this gene for Homo sapiens is present as FOXO4
- CellAge
- A homolog of this gene for Homo sapiens is present as FOXO4
Homologs
- Caenorhabditis elegans
- let-381
- Danio rerio
- si:ch211-206a7.2
- Homo sapiens
- FOXO4
- Mus musculus
- Foxo3
- Rattus norvegicus
- Foxo3
External links
- FlyBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 41709
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar