Cell Senescence Entries for FOXO4
- Cell Types
- Osteosarcoma, Thyroid gland cancer
- Cell Lines
- A14, U2OS
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- de Keizer et al. (2010) Activation of forkhead box O transcription factors by oncogenic BRAF promotes p21cip1-dependent senescence. Cancer Res 70(21)8526-36 (PubMed)
FOXO4 Gene Information
- HGNC symbol
- FOXO4
- Aliases
- AFX1; MLLT7
- Common name
- forkhead box O4
- Entrez Id
- 4303
- Description
- This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].
FOXO4 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:7517; muscle organ development
GO:6357; regulation of transcription by RNA polymerase II
GO:8285; negative regulation of cell population proliferation
GO:48863; stem cell differentiation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:16525; negative regulation of angiogenesis
GO:8286; insulin receptor signaling pathway
GO:51151; negative regulation of smooth muscle cell differentiation
And 8 more GO terms Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5829; cytosol
GO:785; chromatin
GO:5654; nucleoplasm
Show all GO termsFunction: GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:19899; enzyme binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:140297; DNA-binding transcription factor binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
And 3 more GO terms
Homologs of FOXO4 in Model Organisms
- Danio rerio
- LOC563719
- Drosophila melanogaster
- foxo
- Mus musculus
- Foxo4
- Rattus norvegicus
- Foxo4
- Saccharomyces cerevisiae
- FHL1
- Schizosaccharomyces pombe
- sep1
In other databases
- GenAge model organism genes
- A homolog of this gene for Drosophila melanogaster is present as foxo
- GenAge human genes
- This gene is present as FOXO4
- GenDR gene manipulations
- A homolog of this gene for Drosophila melanogaster is present as foxo
- LongevityMap
- This gene is present as FOXO4
External links
- OMIM
- 300033
- Ensembl
- ENSG00000184481
- Entrez Gene
- 4303
- UniGene
- 584654
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- FOXO4
- GeneCards
- FOXO4