GenDR Dietary Restriction Gene Manipulation: klf-1
Gene Information (Entrez Gene ID: 175404)
- Symbol
- klf-1
- Name
- Kruppel-Like Factor (zinc finger protein)
- Organism
- Caenorhabditis elegans (AnAge)
- Entrez Gene ID
- 175404
Potential relevance to dietary restriction and ageing
- Observations
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Klf-1 is essential for the longevity response to decreased nutrient intake. Loss of klf-1 (RNA interference) does not affect lifespan of animals fed ad libitum, however RNA interference of klf-1 in animals undergoing DR results in a significantly shorter lifespan when compared with control animals. Additionally, loss of klf-1 suppresses the extended longevity of eat-2 mutant animals.
- References
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In other databases
- GenAge model organism genes
- This gene is present as klf-1
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as MSN4
Homologs
External links
- WormBase
- Search
- Ensembl
- Search
- Entrez Gene
- ID 175404
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar