GenDR Dietary Restriction Gene Manipulation: gpa2
Gene Information (Entrez Gene ID: 2541720)
- Symbol
- gpa2
- Aliases
- git8
- Name
- Guanine nucleotide-binding protein alpha-2 subunit
- Organism
- Schizosaccharomyces pombe (AnAge)
- Entrez Gene ID
- 2541720
Potential relevance to dietary restriction and ageing
- Observations
-
Gpa2 (alias git8) encodes the alpha subunit of a heterotrimeric G protein, which acts downstream of GIT3. Git8 activity accelerates aging and inhibits the lifespan-extending effect of DR. Constitutive active mutation of gpa2 decreases chronological lifespan under ad libitum (2% glucose) and almost completely cancels out the lifespan extending effect of DR (0.2% glucose) [2562].
- References
-
In other databases
- GenAge model organism genes
- GenDR gene manipulations
- A homolog of this gene for Saccharomyces cerevisiae is present as GPA2
Homologs
- Caenorhabditis elegans
- gpa-8
- Danio rerio
- gna13b
- Homo sapiens
- GNA15
- Mus musculus
- Gna11
- Rattus norvegicus
- Gna11
- Saccharomyces cerevisiae
- GPA2
External links
- Entrez Gene
- ID 2541720
- Homologues
- Search HomoloGene
- UniProt
- Search
- Internet
- Search Google or Search Google Scholar