GenDR Dietary Restriction Gene Manipulation: hsf-1
Gene Information (Entrez Gene ID: 173078)
Potential relevance to dietary restriction and ageing
- Observations
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RNA interference of hsf-1 suppresses normal dauer formation and life-extension due to insulin-like signalling [985]. hsf-1 overexpression extends mean, median, and maximum lifespan by 37, 35, and 29% [2588]. hsf-1 RNAi abrogates lifespan extension by daf-2(e1370) mutation, but not eat-2(ad1116). HSF-1, like DAF-16, is required for daf-2 mutations to extend lifespan [626]. A mutant allele of hsf-1 slightly decreases lifespan under ad lib, but cancels out the lifespan extension effect of bacterial dilution DR [2565]. Solid DR extends the lifespan of hsf-1 mutant with a premature stop codon, that eliminates activation domain, and that of wild-type to a similar extent [2568]. In another experiment, hsf-1 RNAi attenuated lifespan extension by bacterial dilution DR, but only partially that of daf-2 mutation. hsf-1 RNAi attenuated protection against oxidative stress by bacterial dilution DR. hsf-1 expression was induced by bacterial dilution DR [2569].
- References
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In other databases
- GenAge model organism genes
- This gene is present as hsf-1
- GenAge human genes
- A homolog of this gene for Homo sapiens is present as HSF1
- CellAge
- A homolog of this gene for Homo sapiens is present as HSF1
Homologs
- Homo sapiens
- HSF1
External links
- WormBase
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- Ensembl
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- Entrez Gene
- ID 173078
- Homologues
- Search HomoloGene
- UniProt
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- Internet
- Search Google or Search Google Scholar