GenAge entry for HSF1 (Homo sapiens)

Gene name (HAGRID: 125)

HGNC symbol: HSF1
Aliases: HSTF1
Common name: heat shock transcription factor 1

Potential relevance to the human ageing process

Main reason for selection: Entry selected based on evidence directly linking the gene product to ageing in a non-mammalian animal model
Description: A transcription factor that is activated upon heat shock, HSF1 regulates heat-shock response genes and has been associated with ageing in lower life forms. In roundworms, reducing the activity of a HSF1 homologue appears to accelerate ageing while overexpressing it extends lifespan [626]. In mammals, stress-response appears to diminish with age and it has been reported that HSF1 in aged rats exhibits a decreased ability to bind DNA [458]. Disruption of HSF1 in mice results in multiple defects, including increased prenatal lethality, growth retardation, female infertility, and increased susceptibility to stress [634]. Transgenic mutants overexpressing HSF-1 live longer (median lifespan ~50% higher) and are more thermotolerant [3545]. Although HSF1 has not been directly linked to human ageing, it is possible HSF1 plays some role in human ageing.

Cytogenetic information

Cytogenetic band: 8q24.3
Location: 144,291,588 bp to 144,314,722 bp
Orientation: Plus strand

Display region using the UCSC Genome Browser (GRCh38/hg38)

Protein information

Gene Ontology

Process:

GO:0000122; negative regulation of transcription from RNA polymerase II promoter
GO:0001892; embryonic placenta development
GO:0006468; protein phosphorylation
GO:0006952; defense response
GO:0007143; female meiotic division
GO:0007283; spermatogenesis
GO:0007584; response to nutrient
GO:0008285; negative regulation of cell proliferation
GO:0009299; mRNA transcription
GO:0010667; negative regulation of cardiac muscle cell apoptotic process
GO:0014823; response to activity

And 30 more GO terms

Cellular component:

GO:0000791; euchromatin
GO:0000792; heterochromatin
GO:0005634; nucleus
GO:0005654; nucleoplasm
GO:0005737; cytoplasm
GO:0005829; cytosol
GO:0016605; PML body
GO:0043234; protein complex
GO:0045120; pronucleus
GO:0097165; nuclear stress granule

Function:

GO:0000978; RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0000979; RNA polymerase II core promoter sequence-specific DNA binding
GO:0001078; transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
GO:0001162; RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding
GO:0003677; DNA binding
GO:0003700; transcription factor activity, sequence-specific DNA binding
GO:0005515; protein binding
GO:0019901; protein kinase binding
GO:0031072; heat shock protein binding
GO:0042802; identical protein binding
GO:0043621; protein self-association

And 4 more GO terms

Show all GO terms

Protein interactions and network

Protein-protein interacting partners in GenAge: CREBBP, HSP90AA1, UBE2I, CEBPB, PRKDC, XRCC5, XRCC6, HSF1, SIRT1, HDAC1, HSPA1A, MAPK8, TBP, HSPA8, HDAC2, STUB1
STRING interaction network

Retrieve sequences for HSF1

ORF: ORF
CDS: CDS

Homologs in model organisms

Caenorhabditis elegans: hsf-1
Danio rerio: hsf1
Drosophila melanogaster: Hsf
Mus musculus: Hsf1
Rattus norvegicus: Hsf1
Schizosaccharomyces pombe: hsf1

In other databases

GenAge model organism genes

A homolog of this gene for Caenorhabditis elegans is present as hsf-1

GenDR gene manipulations

A homolog of this gene for Caenorhabditis elegans is present as hsf-1

CellAge

This gene is present as HSF1

Selected references

[3545] Baird et al. (2014) "HSF-1-mediated cytoskeletal integrity determines thermotolerance and life span." Science 346(6207):360-363 (PubMed)
[1970] Westerheide et al. (2009) "Stress-inducible regulation of heat shock factor 1 by the deacetylase SIRT1." Science 323(5917):1063-1066 (PubMed)
[1915] Dai et al. (2007) "Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis." Cell 130(6):1005-1018 (PubMed)
[1470] Frier and Locke (2005) "Preservation of heat stress induced myocardial hsp 72 in aged animals following caloric restriction." Exp. Gerontol. 40(7):615-617 (PubMed)
[1064] Alsbury et al. (2004) "Heat shock proteins can protect aged human and rodent cells from different stressful stimuli." Mech. Ageing Dev. 125(3):201-209 (PubMed)
[985] Morley and Morimoto (2004) "Regulation of longevity in Caenorhabditis elegans by heat shock factor and molecular chaperones." Mol. Biol. Cell 15(2):657-664 (PubMed)
[631] Murtha and Keller (2003) "Characterization of the heat shock response in mature zebrafish (Danio rerio)." Exp. Gerontol. 38(6):683-691 (PubMed)
[626] Hsu et al. (2003) "Regulation of aging and age-related disease by DAF-16 and heat-shock factor." Science 300(5622):1142-1145 (PubMed)
[209] Garigan et al. (2002) "Genetic analysis of tissue aging in Caenorhabditis elegans: a role for heat-shock factor and bacterial proliferation." Genetics 161(3):1101-1112 (PubMed)
[458] Takahashi et al. (2002) "Paradoxical increase of heat-shock response with age in a substrain of F344 rats: comparison between F344/DuCrj and F344/Jcl." Mech. Ageing Dev. 123(12):1605-1615 (PubMed)
Show all references (14 more)