Ageing-related Disease Genes

The following steps are to be used to create a merged data set between ageing-related disease genes and ageing genes, according to user-defined filters.

The genes from steps 1 and 2 will be joined based on entrez id to form a merged set at step 3.

 1. Select an ageing-related disease gene set

Ageing Disease Genes
Results

 Genes and Diseases

Gene Symbol Entrez Id MeSH Disease MeSH Category

 Genes

 Entrez Id list

 2. Select an ageing gene set

Choose an ageing dataset of genes to associate with the disease gene set from the previous step.

Ageing Genes Source GenAge Human*
GenAge Microarray*
LongevityMap*
CellAge*
GenDR Expression**
M. musculus
D. melanogaster
C. elegans
S. cerevisiae
All organisms
M. musculus
D. melanogaster
C. elegans
S. cerevisiae

* Only contains human data
** Only contains mouse data

Results

 Ageing Genes

Homolog Gene Homolog Entrez Source Gene Source Entrez Source Species Source Database

 Gene Name list

 Entrez Id list

 3. View common ageing and ageing-related disease genes (CAD genes)

 Ageing Genes

Gene Symbol Entrez Id Mesh Disease Term Mesh Disease Category Other DBs

 Genes

 4. Gene Functional enrichment

Input genes Disease Genes
Ageing Genes
Merged Genes

GO Domain GO Biological Process
GO Molecular Function
GO Cellular Component
Ajusted p-value cut-off

* default 0.05

GO Domain Accession Name P-value Odds Ratio Bonferroni User genes with User genes without Background genes with Background genes without