LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- Italian (Southern)
- Study Design
- A two-stage case-control study was performed to identify the association between longevity and variation of in homeostasis regulation pathway genes. 317 SNPs in 104 genes were analyzed in 78 cases (≥90 years, median age 98 years, 42 females) and 71 controls (<90 years, median age 67 years, 32 females) in stage 1. Then, 31 candidate SNPs identified in stage 1 (π markers = 0.1) were analyzed in an independent sample composed by 288 cases (≥90 years, median age 92 years, 163 females) and 554 controls (<90 years, median age 67 years, 277 females).
- Conclusions
- After adjustment for multiple testing, no significant association was identified between various SNPs and longevity.
- Identifier
- rs2802288
- In Other Studies (IDs)
- 466 467 919
- Cytogenetic Location
- 6q21
- UCSC Genome Browser
- View 6q21 on the UCSC genome browser
Gene details
- HGNC symbol
- FOXO3
- Aliases
- FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
- Common name
- forkhead box O3
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 101
- OMIM
- 602681
- Ensembl
- ENSG00000118689
- UniProt/Swiss-Prot
- FOXO3_HUMAN
- Entrez Gene
- 2309
- UniGene
- 220950
- HapMap
- View on HapMap