LongevityMap variant
Entry Details
- Longevity Association
- Significant
- Population
- Italian (Southern)
- Study Design
- FOXO3A polymorphisms (rs2802292, rs2764264, and rs13217795) were analyzed for longevity associations in 281 long-lived men (age range 90-108 years) and 195 controls (age range 18-48 years) from the Southern Italian Centenarian Study.
- Conclusions
- rs2802288, a proxy of rs2802292, showed the best allelic association--minor allele frequency (MAF) = 0.49; p = 0.003; odds ratio (OR) = 1.51; 95% confidence interval (CI), 1.15-1.98).
- Identifier
- rs2802288
- In Other Studies (IDs)
- 466 919 2244
- Cytogenetic Location
- 6q21
- UCSC Genome Browser
- View 6q21 on the UCSC genome browser
Gene details
- HGNC symbol
- FOXO3
- Aliases
- FOXO2; AF6q21; FKHRL1; FOXO3A; FKHRL1P2
- Common name
- forkhead box O3
- Description
- This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
- Other longevity studies of this gene
- 101
- OMIM
- 602681
- Ensembl
- ENSG00000118689
- UniProt/Swiss-Prot
- FOXO3_HUMAN
- Entrez Gene
- 2309
- UniGene
- 220950
- HapMap
- View on HapMap