LongevityMap variant
Entry Details
- Longevity Association
- Non-significant
- Population
- American of Japanese origin
- Study Design
- 81 tagSNPs that provided virtually complete coverage of key mTOR genes complex genes MTOR, RPTOR, and RICTOR, as well as RPS6KA1, were tested in 814 males (440 aged 95 years and older, 374 controls) for association with longevity and health span phenotypes.
- Conclusions
- No association was found between genotypes and longevity or aging-related biologic, clinical or functional phenoypes after mutiple test correction.
- Identifier
- rs2292639
- In Other Studies (IDs)
- 2280
- Cytogenetic Location
- 17q25.3
- UCSC Genome Browser
- View 17q25.3 on the UCSC genome browser
Gene details
- HGNC symbol
- RPTOR
- Aliases
- KOG1; Mip1
- Common name
- regulatory associated protein of MTOR complex 1
- Description
- This gene encodes a component of a signaling pathway that regulates cell growth in response to nutrient and insulin levels. The encoded protein forms a stoichiometric complex with the mTOR kinase, and also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. The protein positively regulates the downstream effector ribosomal protein S6 kinase, and negatively regulates the mTOR kinase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
- Other longevity studies of this gene
- 63
- OMIM
- 607130
- Ensembl
- ENSG00000141564
- UniProt/Swiss-Prot
- Q6DKI0_HUMAN
- Entrez Gene
- 57521
- UniGene
- 133044
- HapMap
- View on HapMap
Homologs in model organisms
- Caenorhabditis elegans
- daf-15
- Danio rerio
- rptor
- Drosophila melanogaster
- raptor
- Mus musculus
- Rptor
- Rattus norvegicus
- Rptor
- Saccharomyces cerevisiae
- KOG1
- Schizosaccharomyces pombe
- mip1